Detailed information of TA system TA157389

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 195014..195579
• Replicon: chromosome
• Accession: NZ_CP053664
• Organism: Vibrio fluvialis strain A8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPK20_RS00870
• Protein ID: WP_143683507.1
• Coordinates: 195292..195579 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: HPK20_RS00865
• Protein ID: WP_000086647.1
• Coordinates: 195014..195295 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPK20_RS00845	190714..191673	+	960	WP_171933256.1	ABC transporter permease	-
HPK20_RS00850	191685..193319	+	1635	WP_020328029.1	FGGY-family carbohydrate kinase	-
HPK20_RS00855	194361..194492	-	132	Protein_158	IS66 family insertion sequence element accessory protein TnpB	-
HPK20_RS00860	194474..194887	-	414	Protein_159	winged helix-turn-helix domain-containing protein	-
HPK20_RS00865	195014..195295	+	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPK20_RS00870	195292..195579	+	288	WP_143683507.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPK20_RS00875	196313..196933	+	621	WP_052075146.1	hypothetical protein	-
HPK20_RS00880	197069..197467	+	399	WP_171933257.1	S-adenosylhomocysteine hydrolase	-
HPK20_RS00885	197952..199025	-	1074	WP_171933258.1	UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	194444..194875	431

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11009.65 Da
• Isoelectric Point: 5.1098

>T157389 WP_143683507.1 NZ_CP053664:195292-195579 [Vibrio fluvialis]
MKVVWSPLALQKLSDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQVLSEDDV

Nucleotide

• Length: 288 bp

>T157389 NZ_CP069203:4052430-4052648 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT157389 WP_000086647.1 NZ_CP053664:195014-195295 [Vibrio fluvialis]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT157389 NZ_CP069203:4052029-4052403 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0