Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2705170..2705808 Replicon chromosome
Accession NZ_CP053662
Organism Escherichia coli strain eco-241

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag HPK14_RS13130 Protein ID WP_000813797.1
Coordinates 2705632..2705808 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HPK14_RS13125 Protein ID WP_076611057.1
Coordinates 2705170..2705586 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPK14_RS13105 (2700322) 2700322..2701263 - 942 WP_001251335.1 ABC transporter permease -
HPK14_RS13110 (2701264) 2701264..2702277 - 1014 WP_000220413.1 ABC transporter ATP-binding protein -
HPK14_RS13115 (2702295) 2702295..2703440 - 1146 WP_000047447.1 ABC transporter substrate-binding protein -
HPK14_RS13120 (2703685) 2703685..2705091 - 1407 WP_000760613.1 PLP-dependent aminotransferase family protein -
HPK14_RS13125 (2705170) 2705170..2705586 - 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HPK14_RS13130 (2705632) 2705632..2705808 - 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HPK14_RS13135 (2706030) 2706030..2706260 + 231 WP_000494244.1 YncJ family protein -
HPK14_RS13140 (2706352) 2706352..2708313 - 1962 WP_001309488.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HPK14_RS13145 (2708386) 2708386..2708922 - 537 WP_000429161.1 DNA-binding transcriptional regulator SutR -
HPK14_RS13150 (2709014) 2709014..2710186 + 1173 WP_001236223.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T157366 WP_000813797.1 NZ_CP053662:c2705808-2705632 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T157366 NZ_CP069185:c353732-353637 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT157366 WP_076611057.1 NZ_CP053662:c2705586-2705170 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT157366 NZ_CP069185:353537-353602 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References