Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 829940..830774 | Replicon | chromosome |
| Accession | NZ_CP053662 | ||
| Organism | Escherichia coli strain eco-241 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A8E0IX31 |
| Locus tag | HPK14_RS04020 | Protein ID | WP_000854689.1 |
| Coordinates | 829940..830317 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A8E0IVP8 |
| Locus tag | HPK14_RS04025 | Protein ID | WP_001285599.1 |
| Coordinates | 830394..830774 (-) | Length | 127 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPK14_RS03985 (825135) | 825135..825305 | - | 171 | Protein_783 | IS110 family transposase | - |
| HPK14_RS03990 (825722) | 825722..826655 | - | 934 | Protein_784 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| HPK14_RS03995 (826648) | 826648..827043 | - | 396 | WP_000208382.1 | DUF6088 family protein | - |
| HPK14_RS04000 (827195) | 827195..828175 | + | 981 | WP_000019400.1 | IS5-like element IS5 family transposase | - |
| HPK14_RS04005 (828284) | 828284..829156 | - | 873 | WP_273680296.1 | DUF4942 domain-containing protein | - |
| HPK14_RS04010 (829241) | 829241..829438 | - | 198 | WP_000839250.1 | DUF957 domain-containing protein | - |
| HPK14_RS04015 (829455) | 829455..829943 | - | 489 | WP_000761698.1 | DUF5983 family protein | - |
| HPK14_RS04020 (829940) | 829940..830317 | - | 378 | WP_000854689.1 | TA system toxin CbtA family protein | Toxin |
| HPK14_RS04025 (830394) | 830394..830774 | - | 381 | WP_001285599.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HPK14_RS04030 (830824) | 830824..831468 | - | 645 | Protein_792 | antitoxin of toxin-antitoxin stability system | - |
| HPK14_RS04035 (831487) | 831487..831708 | - | 222 | WP_000692326.1 | DUF987 domain-containing protein | - |
| HPK14_RS04040 (831771) | 831771..832247 | - | 477 | WP_001702597.1 | RadC family protein | - |
| HPK14_RS04045 (832263) | 832263..832736 | - | 474 | WP_002431278.1 | antirestriction protein | - |
| HPK14_RS04050 (833000) | 833000..833821 | - | 822 | WP_001234555.1 | DUF932 domain-containing protein | - |
| HPK14_RS04055 (834000) | 834000..834089 | - | 90 | WP_225385657.1 | DUF905 family protein | - |
| HPK14_RS04060 (834232) | 834232..834687 | - | 456 | WP_000581502.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsM / kpsT / ugd / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF | 806675..832736 | 26061 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14042.07 Da Isoelectric Point: 9.1510
>T157354 WP_000854689.1 NZ_CP053662:c830317-829940 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T157354 NZ_CP069174:c1677-1363 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
Antitoxin
Download Length: 127 a.a. Molecular weight: 13984.78 Da Isoelectric Point: 5.0823
>AT157354 WP_001285599.1 NZ_CP053662:c830774-830394 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
Download Length: 381 bp
>AT157354 NZ_CP069174:c1943-1665 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|