Detailed information of TA system TA157344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 6149..6629
• Replicon: plasmid unamed1
• Accession: NZ_CP053650
• Organism: Xanthomonas axonopodis pv. vasculorum strain NCPPB 796

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: XAV_RS21480
• Protein ID: WP_042825444.1
• Coordinates: 6357..6629 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: XAV_RS21475
• Protein ID: WP_042825456.1
• Coordinates: 6149..6373 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XAV_RS21450	1968..2864	+	897	WP_134984116.1	DNA-binding protein	-
XAV_RS21455	2865..3119	-	255	WP_134984115.1	hypothetical protein	-
XAV_RS21460	3515..3811	-	297	WP_134984114.1	hypothetical protein	-
XAV_RS21465	4097..4405	+	309	WP_042825445.1	MobB mobilization protein	-
XAV_RS21470	4402..6078	+	1677	WP_134984113.1	relaxase/mobilization nuclease domain-containing protein	-
XAV_RS21475	6149..6373	+	225	WP_042825456.1	TraY domain-containing protein	Antitoxin
XAV_RS21480	6357..6629	+	273	WP_042825444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XAV_RS21485	6626..6904	+	279	WP_042825442.1	hypothetical protein	-
XAV_RS21490	7038..7238	+	201	WP_105839321.1	hypothetical protein	-
XAV_RS21495	7228..7542	+	315	Protein_10	hypothetical protein	-
XAV_RS21500	7575..8084	-	510	WP_134984112.1	hypothetical protein	-
XAV_RS21505	8096..10273	-	2178	WP_134984111.1	DotA/TraY family protein	-
XAV_RS21510	10270..10881	-	612	WP_134812953.1	hypothetical protein	-
XAV_RS21515	10839..11123	-	285	WP_134984110.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..13693	13693

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10490.27 Da
• Isoelectric Point: 10.1329

>T157344 WP_042825444.1 NZ_CP053650:6357-6629 [Xanthomonas axonopodis pv. vasculorum]
MAWRIEIDPAAEKELDKLGREVAKRILRFLFDRVAKLDDPRSIGEALKGSKLGEFWKYRVGDYRIIADIQDGALCILIVR
VGNRREVYKR

Nucleotide

• Length: 273 bp

>T157344 NZ_CP069170:c4914327-4914043 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8295.52 Da
• Isoelectric Point: 4.5859

>AT157344 WP_042825456.1 NZ_CP053650:6149-6373 [Xanthomonas axonopodis pv. vasculorum]
MLAIRLPPEIENRLDALAAATGRTKTFYAREAILEHLDDLEDVYLAEQRLADIRAGRTAPVPLEDVMKKYGLAD

Nucleotide

• Length: 225 bp

>AT157344 NZ_CP069170:c4914559-4914317 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA