Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 2441749..2442382 Replicon chromosome
Accession NZ_CP053649
Organism Xanthomonas axonopodis pv. vasculorum strain NCPPB 796

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag XAV_RS10500 Protein ID WP_042821126.1
Coordinates 2441749..2442162 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag XAV_RS10505 Protein ID WP_042821127.1
Coordinates 2442149..2442382 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XAV_RS10475 2436802..2437799 - 998 Protein_2052 IS3 family transposase -
XAV_RS10480 2437865..2439009 + 1145 WP_171890877.1 IS3 family transposase -
XAV_RS10485 2439033..2439695 + 663 Protein_2054 IS5 family transposase -
XAV_RS10490 2439838..2441343 + 1506 WP_042824524.1 conjugal transfer protein TraG N-terminal domain-containing protein -
XAV_RS10495 2441348..2441719 - 372 WP_134812339.1 DUF3742 family protein -
XAV_RS10500 2441749..2442162 - 414 WP_042821126.1 PIN domain-containing protein Toxin
XAV_RS10505 2442149..2442382 - 234 WP_042821127.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
XAV_RS10510 2443089..2443090 - 2 WP_171890878.1 IS5 family transposase -
XAV_RS10515 2443544..2447350 - 3807 WP_171890880.1 avirulence protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2430430..2454972 24542
- inside IScluster/Tn - - 2429141..2442984 13843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-119)

Antitoxin

SpoVT-AbrB domain

(5-45)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15496.95 Da        Isoelectric Point: 5.9826

>T157342 WP_042821126.1 NZ_CP053649:c2442162-2441749 [Xanthomonas axonopodis pv. vasculorum]
MVAGKTKIFLDSNVVLYLLSQDAEKADDAEKLLQRRPVISVQVLNEVTHVCVRKLKMGWDEVGQFLALVREFCKVLPLTV
DVHDRARQLAERHQLSFYDACIVAAAAIEGCQTLYTEDMHHGLIIEESLSIRNPFTT

Download         Length: 414 bp

>T157342 NZ_CP069170:4197261-4197479 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8699.00 Da        Isoelectric Point: 8.8317

>AT157342 WP_042821127.1 NZ_CP053649:c2442382-2442149 [Xanthomonas axonopodis pv. vasculorum]
MQVAKWGNSLAVRLPANVVDALELREGDDIEIVVDEPRLFAVRKKPGPDALLERLRVFRGKLPADFRFNREEANGRG

Download         Length: 234 bp

>AT157342 NZ_CP069170:4196860-4197234 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References