Detailed information of TA system TA157336

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3702103..3702760
• Replicon: chromosome
• Accession: NZ_CP053643
• Organism: Enterobacter hormaechei strain Eh65

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HPC69_RS17750
• Protein ID: WP_058652631.1
• Coordinates: 3702103..3702513 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: HPC69_RS17755
• Protein ID: WP_003863437.1
• Coordinates: 3702494..3702760 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPC69_RS17730 (HPC69_17680)	3698101..3699834	-	1734	WP_003863445.1	single-stranded-DNA-specific exonuclease RecJ	-
HPC69_RS17735 (HPC69_17685)	3699840..3700553	-	714	WP_003863443.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HPC69_RS17740 (HPC69_17690)	3700582..3701478	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
HPC69_RS17745 (HPC69_17695)	3701580..3702101	+	522	WP_003863440.1	flavodoxin FldB	-
HPC69_RS17750 (HPC69_17700)	3702103..3702513	-	411	WP_058652631.1	protein YgfX	Toxin
HPC69_RS17755 (HPC69_17705)	3702494..3702760	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
HPC69_RS17760 (HPC69_17710)	3703055..3704035	+	981	WP_003863435.1	tRNA-modifying protein YgfZ	-
HPC69_RS17765 (HPC69_17715)	3704121..3704780	-	660	WP_003863433.1	hemolysin III family protein	-
HPC69_RS17770 (HPC69_17720)	3705047..3705778	+	732	WP_003863431.1	MurR/RpiR family transcriptional regulator	-
HPC69_RS17775 (HPC69_17725)	3705895..3707328	+	1434	WP_003863430.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16367.25 Da
• Isoelectric Point: 11.6602

>T157336 WP_058652631.1 NZ_CP053643:c3702513-3702103 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIRLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T157336 NZ_CP069170:c345547-345140 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT157336 WP_003863437.1 NZ_CP053643:c3702760-3702494 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT157336 NZ_CP069170:c345794-345528 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5