Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2219776..2220515 Replicon chromosome
Accession NZ_CP053643
Organism Enterobacter hormaechei strain Eh65

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag HPC69_RS10715 Protein ID WP_003857133.1
Coordinates 2219776..2220261 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag HPC69_RS10720 Protein ID WP_003857131.1
Coordinates 2220249..2220515 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPC69_RS10695 (HPC69_10680) 2215929..2216687 - 759 WP_058652201.1 trans-aconitate 2-methyltransferase -
HPC69_RS10700 (HPC69_10685) 2216772..2217356 - 585 WP_001190898.1 GDP-mannose pyrophosphatase nudK -
HPC69_RS10705 (HPC69_10690) 2217443..2218201 + 759 WP_117308965.1 DeoR/GlpR family DNA-binding transcription regulator -
HPC69_RS10710 (HPC69_10695) 2218306..2219598 + 1293 WP_058652202.1 glycosyl hydrolase family 28 protein -
HPC69_RS10715 (HPC69_10700) 2219776..2220261 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
HPC69_RS10720 (HPC69_10705) 2220249..2220515 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
HPC69_RS10725 (HPC69_10710) 2220579..2221508 - 930 WP_003857129.1 LysR family transcriptional regulator -
HPC69_RS10730 (HPC69_10715) 2221638..2223026 + 1389 WP_023314162.1 MFS transporter -
HPC69_RS10735 (HPC69_10720) 2223048..2224043 - 996 WP_003857125.1 DUF2891 domain-containing protein -
HPC69_RS10740 (HPC69_10725) 2224053..2225039 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T157326 WP_003857133.1 NZ_CP053643:c2220261-2219776 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T157326 NZ_CP069159:c2324259-2323978 [Citrobacter sp. R56]
ATGATCATGAGCTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCATGGGCGTACGTCAGGCGTTCTGACAACGCAGGT
AAAACGATTGCGTCACCGTCTCGCTGTTATTGATGCCGCCTGCCATATTAACGATATCGACATGCCAGGCTACAGGCTGC
ACTCGTTGAGCGGCGATCGTGATGGCGTTTGGGCGATATCGGTATCGGGAAACTGGCGAATAACCTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACGCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT157326 WP_003857131.1 NZ_CP053643:c2220515-2220249 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT157326 NZ_CP069159:c2323981-2323697 [Citrobacter sp. R56]
ATGAAAATGGCAAATCATCCCCGCCCGGGGGAGATTATTCAGGAGGCGCTGAACGAACTTAACGTCAGTCTGCGCGAATT
TGCCAGAGCAATGGACATTGCTCCCTCTACAGCAAGCCGGTTGCTAACTGGAAAAGCGGCGCTAACCCCAGAAATGGCGA
TTAAGCTCTCCGTGGTGATCGGCAGCTCACCGCAAATGTGGCTGAATCTGCAAACCGCCTGGAGTCTGACAGAGGCCGAA
AAAACCGTTGATATTTCAAGGCTCCGTCATCTGGCAACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References