Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1059441..1060061 Replicon chromosome
Accession NZ_CP053643
Organism Enterobacter hormaechei strain Eh65

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HPC69_RS05070 Protein ID WP_015571250.1
Coordinates 1059441..1059659 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HPC69_RS05075 Protein ID WP_006809850.1
Coordinates 1059687..1060061 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPC69_RS05040 (HPC69_05035) 1055453..1055713 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HPC69_RS05045 (HPC69_05040) 1055716..1055856 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HPC69_RS05050 (HPC69_05045) 1055853..1056563 - 711 WP_022650493.1 GNAT family protein -
HPC69_RS05055 (HPC69_05050) 1056665..1058125 + 1461 WP_058652690.1 PLP-dependent aminotransferase family protein -
HPC69_RS05060 (HPC69_05055) 1058097..1058564 - 468 WP_022650495.1 YlaC family protein -
HPC69_RS05065 (HPC69_05060) 1058681..1059232 - 552 WP_022650496.1 maltose O-acetyltransferase -
HPC69_RS05070 (HPC69_05065) 1059441..1059659 - 219 WP_015571250.1 HHA domain-containing protein Toxin
HPC69_RS05075 (HPC69_05070) 1059687..1060061 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HPC69_RS05080 (HPC69_05075) 1060572..1063718 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
HPC69_RS05085 (HPC69_05080) 1063741..1064934 - 1194 WP_058652691.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T157325 WP_015571250.1 NZ_CP053643:c1059659-1059441 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T157325 NZ_CP069159:781848-782261 [Citrobacter sp. R56]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCACAGTGGTTGTCCCTGCTTCTTCATGGGTTGGTCGCCGC
ATTGATTTTGTTGATGCCCTGGCCATTGAGCTATACCCCTCTGTGGCTGATATTGCTCTCACTGGTGGTGTTCGATTGCG
TACGCAGCCAGCGGCGTATCAATACTCGTCAGGGTGAGATTAAATTACTGATGGATGGGCGTTTGCGCTGGCAGGGGCTG
GAGTGGGTGATTCAGAGAGCACCCTGGATGCTCAAAACGGGCATGATGTTGCGTTTGCGCTCGGATAGCGGTCGGCGTCA
GCATTTATGGCTGGCGGCAGACAGCATGGACGAAAAAGAATGGCGTGAGTTGCGTCGGGTAATGTTGCAGCAAACGGAAC
AAGAGAAGCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT157325 WP_006809850.1 NZ_CP053643:c1060061-1059687 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT157325 NZ_CP069159:781601-781867 [Citrobacter sp. R56]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCATGCCGTCGTGGTATGCGTGAGCTCGACATTTCCATCATGCCGTT
TTTCGAACATGAGTACGATAGCCTCAGTGATGATGAAAAACGCATTTTTATTCGTTTGCTGGAATGCGATGATCCGGATT
TATTCAACTGGTTAATGAATCATGGTAAACCGGCAGATGCAGAACTGGAGCAGATGGTGAGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References