Detailed information of TA system TA157323

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2768879..2769408
• Replicon: chromosome
• Accession: NZ_CP053640
• Organism: Staphylococcus aureus strain 14505

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HA033_RS13750
• Protein ID: WP_000621175.1
• Coordinates: 2769046..2769408 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: HA033_RS13745
• Protein ID: WP_000948331.1
• Coordinates: 2768879..2769049 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA033_RS13715	2763916..2764476	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
HA033_RS13720	2764684..2765163	+	480	WP_001287087.1	hypothetical protein	-
HA033_RS13725	2765156..2766739	+	1584	WP_001294626.1	PH domain-containing protein	-
HA033_RS13730	2766726..2767217	+	492	WP_001205912.1	PH domain-containing protein	-
HA033_RS13735	2767221..2767580	+	360	WP_000581197.1	holo-ACP synthase	-
HA033_RS13740	2767646..2768794	+	1149	WP_001281154.1	alanine racemase	-
HA033_RS13745	2768879..2769049	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
HA033_RS13750	2769046..2769408	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HA033_RS13755	2769758..2770759	+	1002	WP_000390827.1	PP2C family protein-serine/threonine phosphatase	-
HA033_RS13760	2770878..2771204	+	327	WP_001052491.1	anti-sigma factor antagonist	-
HA033_RS13765	2771206..2771685	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
HA033_RS13770	2771660..2772430	+	771	WP_001041111.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T157323 WP_000621175.1 NZ_CP053640:2769046-2769408 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T157323 NZ_CP069157:c3645699-3645352 [Morganella morganii]
ATGGCCTATTATGCATTATCGACAGGTGTTATTACCTGTTCACAGGCGGCGGGACGCTTCAGACGTAATATGCCTCCGGA
AATTCCGGTTATTCTGCCGGGACGTCTTGCTGTTGATGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAG
ATGCCGCACTGCGGGTCTTGCAGGCAGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCC
AGACGTTTTTATGAGCATACCGGTTTTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCA
GCTGGCAACCGGTATCTATTCTGAATAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT157323 WP_000948331.1 NZ_CP053640:2768879-2769049 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT157323 NZ_CP069157:c3646004-3645699 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTTCACGGACATTTGTCGTCTGCCACCATAACCGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1