Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1254763..1255240 Replicon chromosome
Accession NZ_CP053640
Organism Staphylococcus aureus strain 14505

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HA033_RS06470 Protein ID WP_000052076.1
Coordinates 1255052..1255240 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HA033_RS06465 Protein ID WP_001059690.1
Coordinates 1254763..1255023 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA033_RS06430 1250156..1250872 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
HA033_RS06435 1251020..1251442 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
HA033_RS06440 1251841..1252335 + 495 WP_000569883.1 GNAT family N-acetyltransferase -
HA033_RS06445 1252490..1253107 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
HA033_RS06450 1253180..1253761 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
HA033_RS06455 1253986..1254222 + 237 WP_000349581.1 hypothetical protein -
HA033_RS06460 1254219..1254422 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HA033_RS06465 1254763..1255023 + 261 WP_001059690.1 hypothetical protein Antitoxin
HA033_RS06470 1255052..1255240 + 189 WP_000052076.1 hypothetical protein Toxin
HA033_RS06475 1255428..1255997 + 570 WP_001106658.1 hypothetical protein -
HA033_RS06480 1256085..1256354 + 270 WP_001004398.1 hypothetical protein -
HA033_RS06485 1256431..1256649 + 219 WP_000005886.1 hypothetical protein -
HA033_RS06490 1257141..1257341 - 201 WP_001059082.1 cold-shock protein -
HA033_RS06495 1257698..1258384 - 687 WP_000141557.1 thermonuclease family protein -
HA033_RS06500 1258725..1259246 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T157313 WP_000052076.1 NZ_CP053640:1255052-1255240 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T157313 NZ_CP069133:c3227814-3227500 [Escherichia coli BW25113]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT157313 WP_001059690.1 NZ_CP053640:1254763-1255023 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT157313 NZ_CP069133:c3227503-3227087 [Escherichia coli BW25113]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References