Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1593912..1594389 Replicon chromosome
Accession NZ_CP053639
Organism Staphylococcus aureus strain 14732

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag HA036_RS07980 Protein ID WP_000052078.1
Coordinates 1593912..1594100 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HA036_RS07985 Protein ID WP_001059690.1
Coordinates 1594129..1594389 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA036_RS07950 1589953..1590423 + 471 WP_000824472.1 hypothetical protein -
HA036_RS07955 1590764..1591450 + 687 WP_001548082.1 thermonuclease family protein -
HA036_RS07960 1591807..1592007 + 201 WP_001059082.1 cold-shock protein -
HA036_RS07965 1592503..1592721 - 219 WP_000005886.1 hypothetical protein -
HA036_RS07970 1592783..1593067 - 285 WP_001004395.1 hypothetical protein -
HA036_RS07975 1593155..1593724 - 570 WP_001106654.1 hypothetical protein -
HA036_RS07980 1593912..1594100 - 189 WP_000052078.1 hypothetical protein Toxin
HA036_RS07985 1594129..1594389 - 261 WP_001059690.1 hypothetical protein Antitoxin
HA036_RS07990 1594730..1594933 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HA036_RS07995 1594930..1595166 - 237 WP_000368687.1 hypothetical protein -
HA036_RS08000 1595391..1595972 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
HA036_RS08005 1596045..1596662 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
HA036_RS08010 1596817..1597311 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
HA036_RS08015 1597710..1598132 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
HA036_RS08020 1598280..1598996 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T157297 WP_000052078.1 NZ_CP053639:c1594100-1593912 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T157297 NZ_CP069133:c1264731-1264624 [Escherichia coli BW25113]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT157297 WP_001059690.1 NZ_CP053639:c1594389-1594129 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT157297 NZ_CP069133:1264779-1264845 [Escherichia coli BW25113]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References