157288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2757747..2758276 Replicon chromosome
Accession NZ_CP053636
Organism Staphylococcus aureus strain 14640

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HA037_RS13645 Protein ID WP_000621175.1
Coordinates 2757914..2758276 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag HA037_RS13640 Protein ID WP_000948331.1
Coordinates 2757747..2757917 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA037_RS13610 2752784..2753344 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
HA037_RS13615 2753552..2754031 + 480 WP_001287087.1 hypothetical protein -
HA037_RS13620 2754024..2755607 + 1584 WP_001294626.1 PH domain-containing protein -
HA037_RS13625 2755594..2756085 + 492 WP_001205912.1 PH domain-containing protein -
HA037_RS13630 2756089..2756448 + 360 WP_000581197.1 holo-ACP synthase -
HA037_RS13635 2756514..2757662 + 1149 WP_001281154.1 alanine racemase -
HA037_RS13640 2757747..2757917 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
HA037_RS13645 2757914..2758276 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HA037_RS13650 2758626..2759627 + 1002 WP_173863719.1 PP2C family protein-serine/threonine phosphatase -
HA037_RS13655 2759746..2760072 + 327 WP_001052491.1 anti-sigma factor antagonist -
HA037_RS13660 2760074..2760553 + 480 WP_001190829.1 anti-sigma B factor RsbW -
HA037_RS13665 2760528..2761298 + 771 WP_173863720.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T157288 WP_000621175.1 NZ_CP053636:2757914-2758276 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T157288 NZ_CP069132:c3693443-3693336 [Escherichia coli BW25113]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT157288 WP_000948331.1 NZ_CP053636:2757747-2757917 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT157288 NZ_CP069132:3693492-3693558 [Escherichia coli BW25113]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References