Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2736503..2737017 Replicon chromosome
Accession NZ_CP053636
Organism Staphylococcus aureus strain 14640

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag HA037_RS13550 Protein ID WP_000581792.1
Coordinates 2736808..2737017 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HA037_RS13545 Protein ID WP_000138932.1
Coordinates 2736503..2736796 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA037_RS13525 2731766..2732407 + 642 WP_000483153.1 thiamine phosphate synthase -
HA037_RS13530 2732493..2733365 + 873 WP_000725802.1 membrane protein insertase YidC -
HA037_RS13535 2734178..2734825 - 648 WP_001187630.1 HD domain-containing protein -
HA037_RS13540 2734853..2736337 - 1485 WP_000571549.1 cardiolipin synthase -
HA037_RS13545 2736503..2736796 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
HA037_RS13550 2736808..2737017 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
HA037_RS13555 2737145..2737282 + 138 WP_000828354.1 hypothetical protein -
HA037_RS13560 2737546..2738748 - 1203 WP_001109939.1 rod shape-determining protein RodA -
HA037_RS13565 2739066..2740136 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
HA037_RS13570 2740151..2741509 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T157287 WP_000581792.1 NZ_CP053636:2736808-2737017 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T157287 NZ_CP069132:3270692-3271156 [Escherichia coli BW25113]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT157287 WP_000138932.1 NZ_CP053636:2736503-2736796 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT157287 NZ_CP069132:3270357-3270692 [Escherichia coli BW25113]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References