Detailed information of TA system TA157279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 2362952..2363475
• Replicon: chromosome
• Accession: NZ_CP053636
• Organism: Staphylococcus aureus strain 14640

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A3A5LQI3
• Locus tag: HA037_RS11615
• Protein ID: WP_000074049.1
• Coordinates: 2363209..2363475 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HA037_RS11610
• Protein ID: WP_147696638.1
• Coordinates: 2362952..2363209 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA037_RS11595	2359448..2360197	-	750	WP_000072461.1	CPBP family intramembrane metalloprotease	-
HA037_RS11600	2360393..2361970	+	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
HA037_RS11605	2362138..2362593	-	456	WP_000732076.1	DUF1307 domain-containing protein	-
HA037_RS11610	2362952..2363209	+	258	WP_147696638.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HA037_RS11615	2363209..2363475	+	267	WP_000074049.1	Txe/YoeB family addiction module toxin	Toxin
HA037_RS11620	2363830..2364906	+	1077	WP_001076673.1	M42 family metallopeptidase	-
HA037_RS11625	2365154..2365816	+	663	WP_000923526.1	ATP-binding cassette domain-containing protein	-
HA037_RS11630	2365809..2366585	+	777	WP_000072149.1	iron export ABC transporter permease subunit FetB	-
HA037_RS11635	2366981..2368168	+	1188	WP_000026189.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10676.24 Da
• Isoelectric Point: 10.1597

>T157279 WP_000074049.1 NZ_CP053636:2363209-2363475 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T157279 NZ_CP069132:c2082942-2082688 [Escherichia coli BW25113]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.71 Da
• Isoelectric Point: 4.1353

>AT157279 WP_147696638.1 NZ_CP053636:2362952-2363209 [Staphylococcus aureus]
MIIASPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT157279 NZ_CP069132:c2083190-2082939 [Escherichia coli BW25113]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A3A5LQI3