Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1281676..1282464 Replicon chromosome
Accession NZ_CP053636
Organism Staphylococcus aureus strain 14640

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag HA037_RS06500 Protein ID WP_000525004.1
Coordinates 1282003..1282464 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag HA037_RS06495 Protein ID WP_000333630.1
Coordinates 1281676..1281990 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA037_RS06430 1277274..1277636 - 363 WP_000985976.1 hypothetical protein -
HA037_RS06435 1277651..1277974 - 324 WP_000174994.1 hypothetical protein -
HA037_RS06440 1278053..1278214 - 162 WP_001285948.1 DUF1270 domain-containing protein -
HA037_RS06445 1278227..1278490 - 264 WP_001124198.1 helix-turn-helix domain-containing protein -
HA037_RS06450 1278517..1278732 - 216 WP_001097552.1 hypothetical protein -
HA037_RS06455 1278787..1279152 + 366 WP_001128433.1 hypothetical protein -
HA037_RS06460 1279121..1279366 - 246 WP_001025401.1 DUF2829 domain-containing protein -
HA037_RS06465 1279433..1279813 + 381 WP_000773059.1 DUF2513 domain-containing protein -
HA037_RS06470 1279800..1279997 - 198 WP_001148860.1 hypothetical protein -
HA037_RS06475 1280067..1280279 + 213 WP_000362644.1 hypothetical protein -
HA037_RS06480 1280320..1280469 - 150 WP_000771849.1 hypothetical protein -
HA037_RS06485 1280498..1281274 - 777 WP_001148544.1 Rha family transcriptional regulator -
HA037_RS06490 1281288..1281524 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
HA037_RS06495 1281676..1281990 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
HA037_RS06500 1282003..1282464 + 462 WP_000525004.1 hypothetical protein Toxin
HA037_RS06505 1282492..1282713 + 222 Protein_1255 membrane lipoprotein lipid attachment site-containing protein -
HA037_RS06510 1283007..1283891 + 885 WP_001025527.1 hypothetical protein -
HA037_RS06515 1284196..1285401 + 1206 WP_000264751.1 site-specific integrase -
HA037_RS06520 1285551..1286675 - 1125 WP_000866737.1 glycerate kinase -
HA037_RS06525 1287099..1287419 - 321 WP_000985617.1 bacillithiol system redox-active protein YtxJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1236998..1285401 48403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T157278 WP_000525004.1 NZ_CP053636:1282003-1282464 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T157278 NZ_CP069132:2071046-2071420 [Escherichia coli BW25113]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT157278 WP_000333630.1 NZ_CP053636:1281676-1281990 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT157278 NZ_CP069132:2070589-2070957 [Escherichia coli BW25113]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References