Detailed information of TA system TA157274

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1176150..1176627
• Replicon: chromosome
• Accession: NZ_CP053636
• Organism: Staphylococcus aureus strain 14640

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: HA037_RS05890
• Protein ID: WP_000052076.1
• Coordinates: 1176439..1176627 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: HA037_RS05885
• Protein ID: WP_001059690.1
• Coordinates: 1176150..1176410 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA037_RS05850	1171543..1172259	-	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-
HA037_RS05855	1172407..1172829	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
HA037_RS05860	1173228..1173722	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
HA037_RS05865	1173877..1174494	+	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
HA037_RS05870	1174567..1175148	-	582	WP_001140693.1	phosphoglycerate mutase family protein	-
HA037_RS05875	1175373..1175609	+	237	WP_000349581.1	hypothetical protein	-
HA037_RS05880	1175606..1175809	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
HA037_RS05885	1176150..1176410	+	261	WP_001059690.1	hypothetical protein	Antitoxin
HA037_RS05890	1176439..1176627	+	189	WP_000052076.1	hypothetical protein	Toxin
HA037_RS05895	1176815..1177384	+	570	WP_001106658.1	hypothetical protein	-
HA037_RS05900	1177472..1177756	+	285	WP_001004399.1	hypothetical protein	-
HA037_RS05905	1177818..1178036	+	219	WP_000005886.1	hypothetical protein	-
HA037_RS05910	1178528..1178728	-	201	WP_001059082.1	cold-shock protein	-
HA037_RS05915	1179085..1179771	-	687	WP_000141557.1	thermonuclease family protein	-
HA037_RS05920	1180112..1180633	-	522	WP_000824482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	1146190..1190215	44025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-134)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T157274 WP_000052076.1 NZ_CP053636:1176439-1176627 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T157274 NZ_CP069132:1503539-1503715 [Escherichia coli BW25113]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT157274 WP_001059690.1 NZ_CP053636:1176150-1176410 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT157274 NZ_CP069132:1503761-1504177 [Escherichia coli BW25113]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56