Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 121118..121894 Replicon chromosome
Accession NZ_CP053636
Organism Staphylococcus aureus strain 14640

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag HA037_RS00780 Protein ID WP_000031108.1
Coordinates 121742..121894 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag HA037_RS00775 Protein ID WP_001251224.1
Coordinates 121118..121717 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA037_RS00755 117034..118491 + 1458 WP_000649908.1 ABC transporter permease subunit -
HA037_RS00760 118484..119206 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
HA037_RS00765 119357..120484 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
HA037_RS00770 120489..120959 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
HA037_RS00775 121118..121717 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
HA037_RS00780 121742..121894 + 153 WP_000031108.1 hypothetical protein Toxin
HA037_RS00785 122442..122837 + 396 WP_000901023.1 hypothetical protein -
HA037_RS00790 123033..124418 + 1386 WP_000116228.1 class II fumarate hydratase -
HA037_RS00795 124871..125692 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T157271 WP_000031108.1 NZ_CP053636:121742-121894 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T157271 NZ_CP069132:c1265262-1265155 [Escherichia coli BW25113]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT157271 WP_001251224.1 NZ_CP053636:121118-121717 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT157271 NZ_CP069132:1265309-1265375 [Escherichia coli BW25113]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References