Detailed information of TA system TA157267

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2633812..2634341
• Replicon: chromosome
• Accession: NZ_CP053634
• Organism: Staphylococcus aureus strain 14638

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HA038_RS13095
• Protein ID: WP_000621175.1
• Coordinates: 2633979..2634341 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: HA038_RS13090
• Protein ID: WP_000948331.1
• Coordinates: 2633812..2633982 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA038_RS13060	2628849..2629409	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
HA038_RS13065	2629617..2630096	+	480	WP_001287087.1	hypothetical protein	-
HA038_RS13070	2630089..2631672	+	1584	WP_001294626.1	PH domain-containing protein	-
HA038_RS13075	2631659..2632150	+	492	WP_001205912.1	PH domain-containing protein	-
HA038_RS13080	2632154..2632513	+	360	WP_000581197.1	holo-ACP synthase	-
HA038_RS13085	2632579..2633727	+	1149	WP_001281154.1	alanine racemase	-
HA038_RS13090	2633812..2633982	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
HA038_RS13095	2633979..2634341	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HA038_RS13100	2634691..2635692	+	1002	WP_173863719.1	PP2C family protein-serine/threonine phosphatase	-
HA038_RS13105	2635811..2636137	+	327	WP_001052491.1	anti-sigma factor antagonist	-
HA038_RS13110	2636139..2636618	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
HA038_RS13115	2636593..2637363	+	771	WP_173863720.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T157267 WP_000621175.1 NZ_CP053634:2633979-2634341 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T157267 NZ_CP069132:248784-249182 [Escherichia coli BW25113]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT157267 WP_000948331.1 NZ_CP053634:2633812-2633982 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT157267 NZ_CP069132:248488-248781 [Escherichia coli BW25113]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1