Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2612568..2613082 Replicon chromosome
Accession NZ_CP053634
Organism Staphylococcus aureus strain 14638

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag HA038_RS13000 Protein ID WP_000581792.1
Coordinates 2612873..2613082 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HA038_RS12995 Protein ID WP_000138932.1
Coordinates 2612568..2612861 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA038_RS12975 2607831..2608472 + 642 WP_000483153.1 thiamine phosphate synthase -
HA038_RS12980 2608558..2609430 + 873 WP_000725802.1 membrane protein insertase YidC -
HA038_RS12985 2610243..2610890 - 648 WP_001187630.1 HD domain-containing protein -
HA038_RS12990 2610918..2612402 - 1485 WP_000571549.1 cardiolipin synthase -
HA038_RS12995 2612568..2612861 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
HA038_RS13000 2612873..2613082 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
HA038_RS13005 2613210..2613347 + 138 WP_000828354.1 hypothetical protein -
HA038_RS13010 2613611..2614813 - 1203 WP_001109939.1 rod shape-determining protein RodA -
HA038_RS13015 2615131..2616201 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
HA038_RS13020 2616216..2617574 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T157266 WP_000581792.1 NZ_CP053634:2612873-2613082 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T157266 NZ_CP069132:c242722-242444 [Escherichia coli BW25113]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT157266 WP_000138932.1 NZ_CP053634:2612568-2612861 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT157266 NZ_CP069132:c242985-242725 [Escherichia coli BW25113]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References