Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1281671..1282459 Replicon chromosome
Accession NZ_CP053634
Organism Staphylococcus aureus strain 14638

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag HA038_RS06495 Protein ID WP_000525004.1
Coordinates 1281998..1282459 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag HA038_RS06490 Protein ID WP_000333630.1
Coordinates 1281671..1281985 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA038_RS06425 1277269..1277631 - 363 WP_000985976.1 hypothetical protein -
HA038_RS06430 1277646..1277969 - 324 WP_000174994.1 hypothetical protein -
HA038_RS06435 1278048..1278209 - 162 WP_001285948.1 DUF1270 domain-containing protein -
HA038_RS06440 1278222..1278485 - 264 WP_001124198.1 helix-turn-helix domain-containing protein -
HA038_RS06445 1278512..1278727 - 216 WP_001097552.1 hypothetical protein -
HA038_RS06450 1278782..1279147 + 366 WP_001128433.1 hypothetical protein -
HA038_RS06455 1279116..1279361 - 246 WP_001025401.1 DUF2829 domain-containing protein -
HA038_RS06460 1279428..1279808 + 381 WP_000773059.1 DUF2513 domain-containing protein -
HA038_RS06465 1279795..1279992 - 198 WP_001148860.1 hypothetical protein -
HA038_RS06470 1280062..1280274 + 213 WP_000362644.1 hypothetical protein -
HA038_RS06475 1280315..1280464 - 150 WP_000771849.1 hypothetical protein -
HA038_RS06480 1280493..1281269 - 777 WP_001148544.1 Rha family transcriptional regulator -
HA038_RS06485 1281283..1281519 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
HA038_RS06490 1281671..1281985 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
HA038_RS06495 1281998..1282459 + 462 WP_000525004.1 hypothetical protein Toxin
HA038_RS06500 1282487..1282708 + 222 Protein_1254 membrane lipoprotein lipid attachment site-containing protein -
HA038_RS06505 1283002..1283886 + 885 WP_001025527.1 hypothetical protein -
HA038_RS06510 1284191..1285396 + 1206 WP_000264751.1 site-specific integrase -
HA038_RS06515 1285546..1286670 - 1125 WP_000866737.1 glycerate kinase -
HA038_RS06520 1287094..1287414 - 321 WP_000985617.1 bacillithiol system redox-active protein YtxJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1236993..1285396 48403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T157257 WP_000525004.1 NZ_CP053634:1281998-1282459 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T157257 NZ_CP069082:938584-938946 [Staphylococcus gallinarum]
ATGATGAGAAGAGGAGACGTCTATTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAATTAGACCTGTAGT
TATCATACAGAATGATACTGGAAATAAATATAGTCCTACCGTAATTGTTGCGGCAATTACAGGTAGGATAAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGTAAATATAAACTTGATAAAGATTCGGTGATTTTGCTTGAGCAAATAAGA
ACTTTAGACAAGAAAAGGTTAAAGGAAAAGTTAACATATCTATCTGAAGAGAAGATGAAAGAAGTTAATTATGCCATTGA
CATTAGCTTAGGCCTACATAATGTAAGAAACCACAAGCCTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT157257 WP_000333630.1 NZ_CP053634:1281671-1281985 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT157257 NZ_CP069082:938414-938587 [Staphylococcus gallinarum]
ATGGTAAGTATCACGCAAAGCAGAAATCATAATAGCATAGAACAACTACTAAAAGAAGGTTATTCTCAGATGGCCGATTT
AAACCTCTCCCTTGCAGCAGAAGCTTTTCCATTTGAATGTGAAGCTTGTGATTGCAATGAAATTTATATCAGCTCTAAGA
ATAACAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References