Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1176145..1176622 Replicon chromosome
Accession NZ_CP053634
Organism Staphylococcus aureus strain 14638

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HA038_RS05885 Protein ID WP_000052076.1
Coordinates 1176434..1176622 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HA038_RS05880 Protein ID WP_001059690.1
Coordinates 1176145..1176405 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA038_RS05845 1171538..1172254 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
HA038_RS05850 1172402..1172824 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
HA038_RS05855 1173223..1173717 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
HA038_RS05860 1173872..1174489 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
HA038_RS05865 1174562..1175143 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
HA038_RS05870 1175368..1175604 + 237 WP_000349581.1 hypothetical protein -
HA038_RS05875 1175601..1175804 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HA038_RS05880 1176145..1176405 + 261 WP_001059690.1 hypothetical protein Antitoxin
HA038_RS05885 1176434..1176622 + 189 WP_000052076.1 hypothetical protein Toxin
HA038_RS05890 1176810..1177379 + 570 WP_001106658.1 hypothetical protein -
HA038_RS05895 1177467..1177751 + 285 WP_001004399.1 hypothetical protein -
HA038_RS05900 1177813..1178031 + 219 WP_000005886.1 hypothetical protein -
HA038_RS05905 1178523..1178723 - 201 WP_001059082.1 cold-shock protein -
HA038_RS05910 1179080..1179766 - 687 WP_000141557.1 thermonuclease family protein -
HA038_RS05915 1180107..1180628 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1146185..1190210 44025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-213)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T157253 WP_000052076.1 NZ_CP053634:1176434-1176622 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T157253 NZ_CP069080:c4413330-4412689 [Pseudomonas putida]
ATGATTTATTCCAGTCTCAACCCATCCAAGGCACTCATCTGGCGAATTGTTCACCGCGATAACCTGTCGTGGGTTCTGGA
TCATGGGCTGCACGCTGTCTCCTCCGGGAAGCTTTCCAGCACCTACGTTGGAATTGGCAATCCAGAGCTGATCAGCAAGC
GAGCGCAACGCCGTGTGCCTCTGGAACCCAATGGGACGCTGGCGGATTATGTACCGTTCTACTTCACCCCGTTCTCCGTG
ATGATGAAGAATATTCATTCGGGGTGGGGTGTTCCTCAGCGGCGGAACGAAGAGATCGTGATTCTTGTCTCCAGCCTGTA
CCATGCGCAGTCGCTGGGTTTGCAGTTTGTGTTCACGGATGCCCATGCCTACCCGCATTGGGCCGGCTACTACAGTGACC
TCACGCAGCTTGACAAAATCGATTGGGAGATTTTGCAGCGCAGGGATTTCAAACGTGACCCTGATGACCCTCGGAAAATG
GAGCGTTATCAGGCGGAGGCCCTTATCCATGGACATGTCCCAGTTGCTGCCCTTCTGGGAATTGTCTGCTACAACGAAGC
TTTGAAGGGGCGTGTCGACAAGGAGGTTCAGCAACGTCGATTGAATCTCCCTGTGTATGCTCGTCCTGGGTGGTACTTCT
AA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT157253 WP_001059690.1 NZ_CP053634:1176145-1176405 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT157253 NZ_CP069080:c4412689-4411601 [Pseudomonas putida]
ATGATCCACTTTATGCAAGGTAACCTGCTGGAGGCCAAGGCCGAAGCGCTGGTTAACACAGTTAACACCGTAGGGGTGAT
GGGGAAAGGCATCGCGCTGATGTTCAAGGAGCGTTTTGTCGAGAACTATCGCCAGTATGCTGCTGCCTGCAAAGCGAAAG
AGGTAGTTACCGGGAAGATGTTTGTTACTGAAGTGCGTGAGCTGGACGGTCCACGCTGGATTGTGAATTTTCCAACCAAG
CGGCATTGGCGCTCACCTTCGCAAATCGGCTGGATCGTCGAGGGCCTTCATGATTTGCGCAACTTCATTATCAATAACCA
GGTGGCATCGATTGCTATCCCTCCACTTGGTGCTGGTAATGGAGGGTTGTCTTGGGCTGCGGTACGAGAACAGATTCAGA
GGGTTCTGGGTGATCTGGACGCGGATGTTTTCGTTTTCGAGCCTACGGCAAATTATCAAAACGTTTCCAAGCGCAGTGGT
GTTGAGGTTTTGACCCCGGCTCGAGCCTTGATTGCAGAGCTTGTGCGCCGCTATTGGGTGCTGGGGATGGAGTGCAGCTT
GCTCGAAGTCCAGAAGCTTGCCTGGTTTCTGGAGCGATCAATCGAGCGGTTCACGCCAGGCATCAACCCATTGGAATTGA
AGTTTGTCGCTCATAAGTATGGTCCTTACGCCAACCGGCTTGAGCACCTTCTAGATAACCTGGATGGCAGTTATTTACAC
TGCCGAAAGCGGATCAGCGATGCAGGCCCTCTGGACGTTATCTGGTTTGATGAGGGGCGCAAGTCATTTTTACAGGCGTA
TCTGAACAGTGAAGCCAAGGCCTATTTGCCGGCGTTGGAGTTCACTGCCGAGTTGATTGATGGTTTCGAGTCTCCGTTTG
GTATGGAGCTGCTGGCCACCGTTGATTGGTTATTGCATGAAGATGGTGTTGAGCCGACAGTCCCTGCAGTTCGCGAACAC
CTGAAAAATTGGTCAGGAGGGGTAGGTGCCGCTGCTCGAAAAAGCAAACTGTTCGATGACGAGGCACTTGGAATCGCTCT
TCAAAAGCTGTCAATGTTTCGATCCGACCCAGCCACCTCGCTTCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References