Detailed information of TA system TA157243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1327223..1327794
• Replicon: chromosome
• Accession: NZ_CP053627
• Organism: Xylella taiwanensis strain PLS229

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PLS229_RS05700
• Protein ID: WP_038271291.1
• Coordinates: 1327223..1327534 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Z9JJZ2
• Locus tag: PLS229_RS05705
• Protein ID: WP_038271292.1
• Coordinates: 1327522..1327794 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLS229_RS05665	1322267..1323415	+	1149	WP_038273097.1	replication initiation factor domain-containing protein	-
PLS229_RS05670	1323461..1323754	+	294	WP_038273093.1	hypothetical protein	-
PLS229_RS05675	1323757..1323963	+	207	WP_038273092.1	hypothetical protein	-
PLS229_RS05680	1323972..1324190	+	219	WP_051482398.1	phage coat protein	-
PLS229_RS05685	1324658..1325725	+	1068	WP_152536670.1	hypothetical protein	-
PLS229_RS05690	1325729..1326070	+	342	WP_038273089.1	DUF2523 domain-containing protein	-
PLS229_RS05695	1326070..1327218	+	1149	WP_069636227.1	hypothetical protein	-
PLS229_RS05700	1327223..1327534	-	312	WP_038271291.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PLS229_RS05705	1327522..1327794	-	273	WP_038271292.1	CopG family ribbon-helix-helix protein	Antitoxin
PLS229_RS05710	1328136..1329008	+	873	WP_051482318.1	site-specific integrase	-
PLS229_RS05715	1329021..1329413	-	393	WP_051482319.1	hypothetical protein	-
PLS229_RS05720	1329600..1329758	-	159	WP_160165178.1	hypothetical protein	-
PLS229_RS05725	1329755..1330333	-	579	WP_081755441.1	lysozyme	-
PLS229_RS05730	1330349..1330561	-	213	WP_038271294.1	hypothetical protein	-
PLS229_RS05735	1330639..1331013	-	375	WP_038271295.1	DUF2190 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1312178..1335620	23442

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11538.05 Da
• Isoelectric Point: 5.5468

>T157243 WP_038271291.1 NZ_CP053627:c1327534-1327223 [Xylella taiwanensis]
VPQVIVTEGAAEGLERCRQFLATKSSEAAKRASQAIEEQLLLLETAPDIGRPFHEMPEMRELIIAFGKSGYVALYRHESI
DDAVYILAFRHQKEAGYHDHSPS

Nucleotide

• Length: 312 bp

>T157243 NZ_CP069078:c3702146-3701718 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10710.99 Da
• Isoelectric Point: 9.0378

>AT157243 WP_038271292.1 NZ_CP053627:c1327794-1327522 [Xylella taiwanensis]
MATSLKIDNTLKSRVEHLANQRRRSAHWIMLEAIQQYVEREEARDSFKQEALASWAAYKETNRHLTGQEVRTWLNTWGTK
NERETPECHK

Nucleotide

• Length: 273 bp

>AT157243 NZ_CP069078:c3702392-3702150 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Antitoxin

• AlphaFold DB: Z9JJZ2