Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3283125..3283698 Replicon chromosome
Accession NZ_CP053618
Organism Achromobacter xylosoxidans strain GN008

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HPS43_RS15400 Protein ID WP_110059925.1
Coordinates 3283321..3283698 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HPS43_RS15395 Protein ID WP_054471260.1
Coordinates 3283125..3283334 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPS43_RS15375 3278531..3279319 - 789 WP_049054627.1 helix-turn-helix transcriptional regulator -
HPS43_RS15380 3279418..3280344 + 927 WP_020924995.1 DMT family transporter -
HPS43_RS15385 3280357..3281175 - 819 WP_054472847.1 AAC(3) family N-acetyltransferase -
HPS43_RS15390 3281327..3283000 + 1674 WP_006388972.1 energy-dependent translational throttle protein EttA -
HPS43_RS15395 3283125..3283334 + 210 WP_054471260.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HPS43_RS15400 3283321..3283698 + 378 WP_110059925.1 type II toxin-antitoxin system VapC family toxin Toxin
HPS43_RS15405 3283766..3284299 + 534 WP_054480708.1 isochorismatase family protein -
HPS43_RS15410 3284490..3284714 + 225 WP_006388976.1 glycine zipper 2TM domain-containing protein -
HPS43_RS15415 3284844..3285101 - 258 WP_006388977.1 cell division topological specificity factor MinE -
HPS43_RS15420 3285105..3285920 - 816 WP_006388978.1 septum site-determining protein MinD -
HPS43_RS15425 3286110..3287027 - 918 WP_047992558.1 septum site-determining protein MinC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13832.09 Da        Isoelectric Point: 6.3721

>T157236 WP_110059925.1 NZ_CP053618:3283321-3283698 [Achromobacter xylosoxidans]
MILVDTSIWIDHLSDGEPCLVRLLEEESVLMHPFIAGELALGSLGRRDVVLGAMSLLPQVVRASHDEVMHFLHSERLFGK
GIGYVDLHLLASTRLTPGAGLWTRDKRLQALATTLSLAVDPPRYH

Download         Length: 378 bp

>T157236 NZ_CP069078:c3064599-3064204 [Mycobacterium tuberculosis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7521.62 Da        Isoelectric Point: 9.9435

>AT157236 WP_054471260.1 NZ_CP053618:3283125-3283334 [Achromobacter xylosoxidans]
VRTTVTLDDDLLELARTYTGVQETSALVTRALTQLVQKEAAKRLAKLGGSSPKLKPIPRRQTETCNDPG

Download         Length: 210 bp

>AT157236 NZ_CP069078:c3064178-3063912 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References