Detailed information of TA system TA157235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 843654..844218
• Replicon: chromosome
• Accession: NZ_CP053618
• Organism: Achromobacter xylosoxidans strain GN008

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0D6IHV7
• Locus tag: HPS43_RS03995
• Protein ID: WP_020926667.1
• Coordinates: 843654..843935 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0D6IHW1
• Locus tag: HPS43_RS04000
• Protein ID: WP_020926666.1
• Coordinates: 843922..844218 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPS43_RS03970	838685..839188	-	504	WP_047993287.1	flavin reductase family protein	-
HPS43_RS03975	839212..840225	-	1014	WP_173010438.1	LLM class flavin-dependent oxidoreductase	-
HPS43_RS03980	840347..841180	+	834	WP_054500088.1	IclR family transcriptional regulator	-
HPS43_RS03985	841416..842471	+	1056	WP_173010439.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
HPS43_RS03990	842468..843604	+	1137	WP_054442896.1	tRNA guanosine(34) transglycosylase Tgt	-
HPS43_RS03995	843654..843935	-	282	WP_020926667.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPS43_RS04000	843922..844218	-	297	WP_020926666.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPS43_RS04005	844590..844934	+	345	WP_006386647.1	preprotein translocase subunit YajC	-
HPS43_RS04010	845050..846930	+	1881	WP_006386648.1	protein translocase subunit SecD	-
HPS43_RS04015	846982..847917	+	936	WP_006386649.1	protein translocase subunit SecF	-
HPS43_RS04020	848087..848455	+	369	Protein_787	type II toxin-antitoxin system RelE/ParE family toxin	-
HPS43_RS04025	848452..848763	+	312	WP_006386651.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-52)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10262.77 Da
• Isoelectric Point: 7.0080

>T157235 WP_020926667.1 NZ_CP053618:c843935-843654 [Achromobacter xylosoxidans]
VPAVEWSSAARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPARPALYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Nucleotide

• Length: 282 bp

>T157235 NZ_CP069078:c3063915-3063499 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10717.24 Da
• Isoelectric Point: 7.3208

>AT157235 WP_020926666.1 NZ_CP053618:c844218-843922 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Nucleotide

• Length: 297 bp

>AT157235 NZ_CP069078:c3064178-3063912 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Structures

Toxin

• AlphaFold DB: A0A0D6IHV7

Antitoxin

• AlphaFold DB: A0A0D6IHW1