Detailed information of TA system TA157234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 5473135..5473815
• Replicon: chromosome
• Accession: NZ_CP053617
• Organism: Achromobacter xylosoxidans strain GN050

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HPS44_RS24960
• Protein ID: WP_006386381.1
• Coordinates: 5473135..5473320 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HPS44_RS24965
• Protein ID: WP_006386380.1
• Coordinates: 5473396..5473815 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPS44_RS24950	5469271..5470674	+	1404	WP_047992789.1	dihydrolipoyl dehydrogenase	-
HPS44_RS24955	5470849..5472888	-	2040	WP_173001172.1	pyruvate, phosphate dikinase	-
HPS44_RS24960	5473135..5473320	+	186	WP_006386381.1	type II toxin-antitoxin system HicA family toxin	Toxin
HPS44_RS24965	5473396..5473815	+	420	WP_006386380.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HPS44_RS24970	5473906..5475324	-	1419	WP_006386379.1	argininosuccinate lyase	-
HPS44_RS24975	5475537..5476868	+	1332	WP_026382696.1	mechanosensitive ion channel	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-94)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7058.16 Da
• Isoelectric Point: 10.6654

>T157234 WP_006386381.1 NZ_CP053617:5473135-5473320 [Achromobacter xylosoxidans]
MKYSEFKKWLERQGAVFVAHRSGSSHFRVTLNGATTIFPYHGSKEMGKHLEHEIKKQLGLK

Nucleotide

• Length: 186 bp

>T157234 NZ_CP069078:c2970602-2970279 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15506.81 Da
• Isoelectric Point: 4.9597

>AT157234 WP_006386380.1 NZ_CP053617:5473396-5473815 [Achromobacter xylosoxidans]
MLTYPFTLTLDSNRTWLVRFPDIPEALTVGDDEQEAAINAREALEAALEIYFDARRPIPLPSPVSAGQASVTLPALITSK
VFLSNEMIQQGVRKAELARRMGVHMPQVDRLLDVRHASRIEQVESALEQLGRRLEVSLA

Nucleotide

• Length: 420 bp

>AT157234 NZ_CP069078:c2970927-2970682 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA