Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 5444048..5444670 Replicon chromosome
Accession NZ_CP053617
Organism Achromobacter xylosoxidans strain GN050

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPS44_RS24850 Protein ID WP_054505594.1
Coordinates 5444356..5444670 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HPS44_RS24845 Protein ID WP_054508121.1
Coordinates 5444048..5444359 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPS44_RS24805 5439057..5439305 + 249 WP_020927249.1 acyl carrier protein -
HPS44_RS24810 5439321..5440214 + 894 WP_026382709.1 diiron oxygenase -
HPS44_RS24815 5440229..5441185 + 957 WP_173001132.1 nitronate monooxygenase -
HPS44_RS24820 5441243..5442028 + 786 WP_006386406.1 hypothetical protein -
HPS44_RS24825 5442029..5442412 + 384 WP_006386405.1 hypothetical protein -
HPS44_RS24830 5442387..5442905 + 519 WP_150100285.1 4'-phosphopantetheinyl transferase superfamily protein -
HPS44_RS24840 5443169..5443951 - 783 WP_006386403.1 exodeoxyribonuclease III -
HPS44_RS24845 5444048..5444359 - 312 WP_054508121.1 putative addiction module antidote protein Antitoxin
HPS44_RS24850 5444356..5444670 - 315 WP_054505594.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPS44_RS24855 5445093..5448434 + 3342 WP_173001138.1 viral (Super1) RNA helicase -
HPS44_RS24860 5448471..5448727 - 257 Protein_4899 SDR family oxidoreductase -
HPS44_RS24865 5448834..5449637 - 804 WP_020927258.1 FadR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(51-95)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11792.46 Da        Isoelectric Point: 8.5141

>T157233 WP_054505594.1 NZ_CP053617:c5444670-5444356 [Achromobacter xylosoxidans]
MYHIKPLPEFDAWFDTLTDPATRARLIRRLEKAARGLLGDVKPVGEGVSEMREFFGPGWRMYYAERGNVLIVMLGGGTKG
TQSRDVKHAKELARALRNDEEDQS

Download         Length: 315 bp

>T157233 NZ_CP069078:2925389-2925829 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11104.80 Da        Isoelectric Point: 8.9514

>AT157233 WP_054508121.1 NZ_CP053617:c5444359-5444048 [Achromobacter xylosoxidans]
MSKKAIKISELPTFDPARYLRDDKDIAAYLTQVIEDGDFGELAQALGVAARARGMTQIAETTGIGRESLYKALRAGASPR
FDTIAKVCKALGVRLVVQAEHPA

Download         Length: 312 bp

>AT157233 NZ_CP069078:2925115-2925402 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References