Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4126502..4127075 Replicon chromosome
Accession NZ_CP053617
Organism Achromobacter xylosoxidans strain GN050

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HPS44_RS18765 Protein ID WP_049054629.1
Coordinates 4126698..4127075 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HPS44_RS18760 Protein ID WP_054471260.1
Coordinates 4126502..4126711 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPS44_RS18740 4121909..4122697 - 789 WP_173000813.1 helix-turn-helix transcriptional regulator -
HPS44_RS18745 4122796..4123722 + 927 WP_173000814.1 DMT family transporter -
HPS44_RS18750 4123735..4124553 - 819 WP_173000815.1 AAC(3) family N-acetyltransferase -
HPS44_RS18755 4124704..4126377 + 1674 WP_006388972.1 energy-dependent translational throttle protein EttA -
HPS44_RS18760 4126502..4126711 + 210 WP_054471260.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HPS44_RS18765 4126698..4127075 + 378 WP_049054629.1 type II toxin-antitoxin system VapC family toxin Toxin
HPS44_RS18770 4127143..4127676 + 534 WP_173000816.1 isochorismatase family protein -
HPS44_RS18775 4127867..4128091 + 225 WP_006388976.1 glycine zipper 2TM domain-containing protein -
HPS44_RS18780 4128221..4128478 - 258 WP_006388977.1 cell division topological specificity factor MinE -
HPS44_RS18785 4128482..4129297 - 816 WP_006388978.1 septum site-determining protein MinD -
HPS44_RS18790 4129486..4130403 - 918 WP_107315901.1 septum site-determining protein MinC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13846.11 Da        Isoelectric Point: 6.3721

>T157232 WP_049054629.1 NZ_CP053617:4126698-4127075 [Achromobacter xylosoxidans]
MILVDTSIWIDHLSDGEPCLVRLLEEESVLMHPFIAGELALGSLGRRDVVLGAMSLLPQVVRASHDEVMHFLHSERLFGK
GIGYVDLHLLASTRLTPGAALWTRDKRLQALATTLSLAVDPPRYH

Download         Length: 378 bp

>T157232 NZ_CP069078:c2865167-2864772 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7521.62 Da        Isoelectric Point: 9.9435

>AT157232 WP_054471260.1 NZ_CP053617:4126502-4126711 [Achromobacter xylosoxidans]
VRTTVTLDDDLLELARTYTGVQETSALVTRALTQLVQKEAAKRLAKLGGSSPKLKPIPRRQTETCNDPG

Download         Length: 210 bp

>AT157232 NZ_CP069078:c2865409-2865164 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References