Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 2369572..2370179 Replicon chromosome
Accession NZ_CP053617
Organism Achromobacter xylosoxidans strain GN050

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HPS44_RS10690 Protein ID WP_173001488.1
Coordinates 2369871..2370179 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HPS44_RS10685 Protein ID WP_054446746.1
Coordinates 2369572..2369874 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPS44_RS10675 2364993..2365226 + 234 WP_050807714.1 antitoxin VbhA family protein -
HPS44_RS10680 2365309..2369277 + 3969 WP_198918223.1 SIR2 family protein -
HPS44_RS10685 2369572..2369874 - 303 WP_054446746.1 putative addiction module antidote protein Antitoxin
HPS44_RS10690 2369871..2370179 - 309 WP_173001488.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPS44_RS10695 2370545..2371147 + 603 WP_173000026.1 hypothetical protein -
HPS44_RS10700 2371194..2371541 - 348 WP_173000027.1 YXWGXW repeat-containing protein -
HPS44_RS10705 2371833..2372849 + 1017 WP_006385707.1 amino acid ABC transporter substrate-binding protein -
HPS44_RS10710 2372996..2373982 - 987 WP_082387743.1 DUF3578 domain-containing protein -
HPS44_RS10715 2374220..2374501 + 282 WP_006385706.1 peptidyl-prolyl cis-trans isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(4-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11556.45 Da        Isoelectric Point: 10.8744

>T157230 WP_173001488.1 NZ_CP053617:c2370179-2369871 [Achromobacter xylosoxidans]
MLRFRETDVFSRWITELRDARAKAHIVRRLARAMVGNFGDVAPVGDGISEMRIDVGTGYRVYYRRQGPVVYVLLCGGDKA
SQARDIVTAKRLWSELKGKALK

Download         Length: 309 bp

>T157230 NZ_CP069078:2863199-2863612 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10538.90 Da        Isoelectric Point: 5.0028

>AT157230 WP_054446746.1 NZ_CP053617:c2369874-2369572 [Achromobacter xylosoxidans]
MIQLRDFDPANYLSDDEAIAHYLADAAADPDPDAFLQALGDVARARGIGAIAKETGLARTNLYRVLAPGANPSYLTLRRV
MDALGVSLTAVSKGKDAAHA

Download         Length: 303 bp

>AT157230 NZ_CP069078:2863651-2863908 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References