Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1733939..1734503 Replicon chromosome
Accession NZ_CP053617
Organism Achromobacter xylosoxidans strain GN050

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6IHV7
Locus tag HPS44_RS07760 Protein ID WP_020926667.1
Coordinates 1733939..1734220 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag HPS44_RS07765 Protein ID WP_020926666.1
Coordinates 1734207..1734503 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPS44_RS07735 1728971..1729474 - 504 WP_006386642.1 flavin reductase family protein -
HPS44_RS07740 1729498..1730511 - 1014 WP_026384955.1 LLM class flavin-dependent oxidoreductase -
HPS44_RS07745 1730633..1731466 + 834 WP_070781838.1 IclR family transcriptional regulator -
HPS44_RS07750 1731701..1732756 + 1056 WP_054514754.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
HPS44_RS07755 1732753..1733889 + 1137 WP_054442896.1 tRNA guanosine(34) transglycosylase Tgt -
HPS44_RS07760 1733939..1734220 - 282 WP_020926667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPS44_RS07765 1734207..1734503 - 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPS44_RS07770 1734875..1735219 + 345 WP_006386647.1 preprotein translocase subunit YajC -
HPS44_RS07775 1735335..1737215 + 1881 WP_006386648.1 protein translocase subunit SecD -
HPS44_RS07780 1737267..1738202 + 936 WP_006386649.1 protein translocase subunit SecF -
HPS44_RS07785 1738372..1738740 + 369 WP_172999868.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPS44_RS07790 1738737..1739048 + 312 WP_006386651.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10262.77 Da        Isoelectric Point: 7.0080

>T157229 WP_020926667.1 NZ_CP053617:c1734220-1733939 [Achromobacter xylosoxidans]
VPAVEWSSAARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPARPALYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

>T157229 NZ_CP069078:c2849781-2849362 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT157229 WP_020926666.1 NZ_CP053617:c1734503-1734207 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp

>AT157229 NZ_CP069078:c2850002-2849778 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6IHV7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References