Detailed information of TA system TA157227

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3536386..3537957
• Replicon: chromosome
• Accession: NZ_CP053616
• Organism: Proteus mirabilis strain MPE0767

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B4F0T8
• Locus tag: HPT03_RS16455
• Protein ID: WP_012368637.1
• Coordinates: 3536644..3537957 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: HPT03_RS16450
• Protein ID: WP_004249771.1
• Coordinates: 3536386..3536643 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPT03_RS16425	3532348..3532491	+	144	WP_004246509.1	50S ribosomal protein L34	-
HPT03_RS16430	3532509..3532868	+	360	WP_004246510.1	ribonuclease P protein component	-
HPT03_RS16435	3532832..3533092	+	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
HPT03_RS16440	3533095..3534735	+	1641	WP_004246512.1	membrane protein insertase YidC	-
HPT03_RS16445	3534873..3536237	+	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
HPT03_RS16450	3536386..3536643	+	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
HPT03_RS16455	3536644..3537957	+	1314	WP_012368637.1	type II toxin-antitoxin system HipA family toxin	Toxin
HPT03_RS16460	3538360..3538824	+	465	WP_049256373.1	DUF1097 domain-containing protein	-
HPT03_RS16465	3539009..3539938	+	930	WP_004246518.1	metallophosphoesterase	-
HPT03_RS16470	3539970..3541931	+	1962	WP_036971861.1	hypothetical protein	-
HPT03_RS16475	3541985..3542788	-	804	WP_004249775.1	energy transducer TonB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49670.78 Da
• Isoelectric Point: 6.5023

>T157227 WP_012368637.1 NZ_CP053616:3536644-3537957 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T157227 NZ_CP069078:c2409325-2409008 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT157227 WP_004249771.1 NZ_CP053616:3536386-3536643 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT157227 NZ_CP069078:c2409537-2409322 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: B4F0T8

Antitoxin

• AlphaFold DB: B4F0T9