Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3517736..3518337 Replicon chromosome
Accession NZ_CP053616
Organism Proteus mirabilis strain MPE0767

Toxin (Protein)


Gene name doc Uniprot ID A0A1Z1SQZ4
Locus tag HPT03_RS16365 Protein ID WP_036895893.1
Coordinates 3517954..3518337 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag HPT03_RS16360 Protein ID WP_004246496.1
Coordinates 3517736..3517957 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPT03_RS16335 3513580..3514038 + 459 WP_004246490.1 dUTP diphosphatase -
HPT03_RS16340 3514158..3514763 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
HPT03_RS16345 3515082..3515726 - 645 WP_004246493.1 orotate phosphoribosyltransferase -
HPT03_RS16350 3515808..3516524 - 717 WP_004249946.1 ribonuclease PH -
HPT03_RS16355 3516651..3517514 + 864 WP_004249947.1 YicC family protein -
HPT03_RS16360 3517736..3517957 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPT03_RS16365 3517954..3518337 + 384 WP_036895893.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HPT03_RS16370 3518744..3519058 + 315 WP_004246498.1 helix-turn-helix domain-containing protein -
HPT03_RS16375 3519358..3520257 - 900 WP_017826985.1 N-acetylmuramic acid 6-phosphate etherase -
HPT03_RS16380 3520366..3521103 + 738 WP_004249950.1 sel1 repeat family protein -
HPT03_RS16385 3521199..3521657 - 459 WP_049203077.1 GNAT family N-acetyltransferase -
HPT03_RS16390 3521786..3523273 + 1488 WP_049208367.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14518.52 Da        Isoelectric Point: 8.4945

>T157226 WP_036895893.1 NZ_CP053616:3517954-3518337 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNTLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T157226 NZ_CP069078:c2372695-2372261 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT157226 WP_004246496.1 NZ_CP053616:3517736-3517957 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT157226 NZ_CP069078:c2372956-2372702 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z1SQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References