Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2392268..2392869 Replicon chromosome
Accession NZ_CP053615
Organism Proteus mirabilis strain MPE0734

Toxin (Protein)


Gene name doc Uniprot ID A0A1Z1SQZ4
Locus tag HO271_RS11270 Protein ID WP_036895893.1
Coordinates 2392486..2392869 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag HO271_RS11265 Protein ID WP_004246496.1
Coordinates 2392268..2392489 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO271_RS11240 2388112..2388570 + 459 WP_004246490.1 dUTP diphosphatase -
HO271_RS11245 2388690..2389295 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
HO271_RS11250 2389614..2390258 - 645 WP_004246493.1 orotate phosphoribosyltransferase -
HO271_RS11255 2390340..2391056 - 717 WP_004249946.1 ribonuclease PH -
HO271_RS11260 2391183..2392046 + 864 WP_004249947.1 YicC family protein -
HO271_RS11265 2392268..2392489 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HO271_RS11270 2392486..2392869 + 384 WP_036895893.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HO271_RS11275 2393276..2393590 + 315 WP_004246498.1 helix-turn-helix domain-containing protein -
HO271_RS11280 2393890..2394789 - 900 WP_017826985.1 N-acetylmuramic acid 6-phosphate etherase -
HO271_RS11285 2394898..2395635 + 738 WP_004249950.1 sel1 repeat family protein -
HO271_RS11290 2395731..2396189 - 459 WP_049203077.1 GNAT family N-acetyltransferase -
HO271_RS11295 2396318..2397805 + 1488 WP_049208367.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14518.52 Da        Isoelectric Point: 8.4945

>T157220 WP_036895893.1 NZ_CP053615:2392486-2392869 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNTLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T157220 NZ_CP069078:c2211282-2210986 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT157220 WP_004246496.1 NZ_CP053615:2392268-2392489 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT157220 NZ_CP069078:c2211530-2211279 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z1SQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References