Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 184430..185071 Replicon chromosome
Accession NZ_CP053610
Organism Burkholderia sp. MBR-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MBR110_RS15740 Protein ID WP_060091795.1
Coordinates 184733..185071 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MBR110_RS15735 Protein ID WP_011881499.1
Coordinates 184430..184729 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBR110_RS15710 179526..180797 + 1272 WP_014724582.1 Rieske 2Fe-2S domain-containing protein -
MBR110_RS15715 180815..181300 + 486 WP_181709408.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
MBR110_RS15720 181327..181653 + 327 WP_011881496.1 non-heme iron oxygenase ferredoxin subunit -
MBR110_RS15725 181643..182863 + 1221 WP_181709409.1 FAD-dependent oxidoreductase -
MBR110_RS15730 183052..184338 + 1287 WP_059734973.1 DUF445 domain-containing protein -
MBR110_RS15735 184430..184729 - 300 WP_011881499.1 putative addiction module antidote protein Antitoxin
MBR110_RS15740 184733..185071 - 339 WP_060091795.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MBR110_RS15745 185428..187068 + 1641 WP_059463465.1 acetolactate synthase large subunit -
MBR110_RS15750 187097..188530 + 1434 WP_011881502.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-98)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12566.32 Da        Isoelectric Point: 9.5939

>T157215 WP_060091795.1 NZ_CP053610:c185071-184733 [Burkholderia sp. MBR-1]
MVDISSNVPYSAPTSSIRTTEVFDTWFAGLQDRVARRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRA
TIWVILLCGGDKSTQQADIRAAHAMLGRLDLE

Download         Length: 339 bp

>T157215 NZ_CP069078:1762978-1763382 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10548.87 Da        Isoelectric Point: 6.0633

>AT157215 WP_011881499.1 NZ_CP053610:c184729-184430 [Burkholderia sp. MBR-1]
MDKISTRPWDSAAHLETDDDIADYFDACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKARA

Download         Length: 300 bp

>AT157215 NZ_CP069078:1762769-1762972 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References