Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2915814..2916453 Replicon chromosome
Accession NZ_CP053609
Organism Burkholderia sp. MBR-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A132DRA7
Locus tag MBR110_RS13475 Protein ID WP_011883463.1
Coordinates 2915814..2916233 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132DHM6
Locus tag MBR110_RS13480 Protein ID WP_011883461.1
Coordinates 2916220..2916453 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBR110_RS13450 2911237..2911593 - 357 WP_011883473.1 BON domain-containing protein -
MBR110_RS13455 2912062..2913495 + 1434 WP_011883471.1 ABC transporter substrate-binding protein -
MBR110_RS13460 2913590..2914228 + 639 WP_011883469.1 2-hydroxychromene-2-carboxylate isomerase -
MBR110_RS13465 2914298..2915242 + 945 WP_059454482.1 LysR family transcriptional regulator -
MBR110_RS13470 2915283..2915684 - 402 WP_011883465.1 polyketide cyclase -
MBR110_RS13475 2915814..2916233 - 420 WP_011883463.1 type II toxin-antitoxin system VapC family toxin Toxin
MBR110_RS13480 2916220..2916453 - 234 WP_011883461.1 DNA-binding protein Antitoxin
MBR110_RS13485 2916780..2917433 - 654 WP_059735734.1 xanthine dehydrogenase accessory protein XdhC -
MBR110_RS13490 2917521..2919884 - 2364 WP_011883458.1 xanthine dehydrogenase molybdopterin binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15649.85 Da        Isoelectric Point: 6.0999

>T157214 WP_011883463.1 NZ_CP053609:c2916233-2915814 [Burkholderia sp. MBR-1]
MFLVDTNVISEVRKRERADKGVMAFFRKAAQDDADLYLSVVTVGELRRGVEIIRHRGDKSQATRLENWLDGVLREFASNI
LAVDEEIGQLWGRLRVPHPEHSLDKLIAATALIHDLIVVTRNVDDFAGTGARVLNPFES

Download         Length: 420 bp

>T157214 NZ_CP069078:1683358-1683675 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8379.44 Da        Isoelectric Point: 5.0644

>AT157214 WP_011883461.1 NZ_CP053609:c2916453-2916220 [Burkholderia sp. MBR-1]
MATLLVRNVDEELVQSLRERAAANGRSAEAEHREILAKALRAPQRKTFAQVLMSIPNVGTDADFARVDDGEAANVFG

Download         Length: 234 bp

>AT157214 NZ_CP069078:1683059-1683361 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132DRA7

Antitoxin

Source ID Structure
AlphaFold DB A0A132DHM6

References