157074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2061730..2062561 Replicon chromosome
Accession NZ_CP053603
Organism Escherichia coli strain Dam/Dcm

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HO395_RS10120 Protein ID WP_000854814.1
Coordinates 2062187..2062561 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag HO395_RS10115 Protein ID WP_001285584.1
Coordinates 2061730..2062098 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO395_RS10100 2059397..2060929 + 1533 WP_001350525.1 hypothetical protein -
HO395_RS10105 2060926..2061372 + 447 WP_000187523.1 RadC family protein -
HO395_RS10110 2061435..2061656 + 222 WP_000692323.1 DUF987 domain-containing protein -
HO395_RS10115 2061730..2062098 + 369 WP_001285584.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HO395_RS10120 2062187..2062561 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
HO395_RS10125 2062558..2062752 + 195 WP_000988600.1 hypothetical protein -
HO395_RS10130 2062765..2062878 + 114 WP_001161660.1 DUF957 domain-containing protein -
HO395_RS10135 2063167..2063295 - 129 Protein_1979 transposase domain-containing protein -
HO395_RS10140 2063367..2063549 + 183 WP_001016348.1 hypothetical protein -
HO395_RS10145 2063650..2063979 - 330 WP_000450409.1 DUF496 family protein -
HO395_RS10150 2064151..2065209 - 1059 WP_001200891.1 FUSC family protein -
HO395_RS10155 2065407..2065880 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
HO395_RS10160 2065999..2067165 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T157074 WP_000854814.1 NZ_CP053603:2062187-2062561 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T157074 NZ_CP069076:359345-359770 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT157074 WP_001285584.1 NZ_CP053603:2061730-2062098 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT157074 NZ_CP069076:359127-359348 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2E8G6

References