Detailed information of TA system TA156910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4390565..4391379
• Replicon: chromosome
• Accession: NZ_CP053592
• Organism: Escherichia coli strain NEBExpress_Iq

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: HO403_RS21160
• Protein ID: WP_001054376.1
• Coordinates: 4391122..4391379 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: HO403_RS21155
• Protein ID: WP_001309181.1
• Coordinates: 4390565..4391110 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HO403_RS21130	4386256..4387569	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
HO403_RS21135	4387581..4387859	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
HO403_RS21140	4387856..4388977	-	1122	WP_000010829.1	M42 family metallopeptidase	-
HO403_RS21145	4389376..4389594	-	219	Protein_4115	hypothetical protein	-
HO403_RS21150	4389763..4390509	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
HO403_RS21155	4390565..4391110	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
HO403_RS21160	4391122..4391379	-	258	WP_001054376.1	hypothetical protein	Toxin
HO403_RS21165	4391756..4392001	-	246	Protein_4119	GNAT family N-acetyltransferase	-
HO403_RS21170	4392371..4393357	+	987	Protein_4120	hypothetical protein	-
HO403_RS21175	4393940..4394920	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
HO403_RS21180	4394985..4396091	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB / fimE / fimA / fimI / fimC	4382545..4403131	20586

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T156910 WP_001054376.1 NZ_CP053592:c4391379-4391122 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T156910 NZ_CP069073:c760506-760198 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT156910 WP_001309181.1 NZ_CP053592:c4391110-4390565 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT156910 NZ_CP069073:c760738-760493 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8