Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/ElaA-DUF1778
Location 108933..109736 Replicon plasmid unnamed
Accession NZ_CP053580
Organism Salmonella enterica strain 94-0093

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag HPG92_RS00530 Protein ID WP_171774034.1
Coordinates 109206..109736 (+) Length 177 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag HPG92_RS00525 Protein ID WP_171774033.1
Coordinates 108933..109202 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPG92_RS00505 105206..105472 + 267 WP_171774031.1 type II toxin-antitoxin system ParD family antitoxin -
HPG92_RS00510 105459..105755 + 297 WP_171774032.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPG92_RS00515 106052..106783 + 732 Protein_102 site-specific integrase -
HPG92_RS00520 107087..108079 - 993 WP_077907168.1 RepB family plasmid replication initiator protein -
HPG92_RS00525 108933..109202 + 270 WP_171774033.1 DUF1778 domain-containing protein Antitoxin
HPG92_RS00530 109206..109736 + 531 WP_171774034.1 GNAT family N-acetyltransferase Toxin
HPG92_RS00535 109782..109968 + 187 Protein_106 transposase -
HPG92_RS00540 110339..110953 - 615 WP_171774035.1 DNA-binding protein -
HPG92_RS00545 112000..112386 + 387 WP_171774036.1 hypothetical protein -
HPG92_RS00550 112422..112931 + 510 WP_171774037.1 hypothetical protein -
HPG92_RS00555 112936..113715 + 780 WP_171774038.1 tyrosine-type recombinase/integrase -
HPG92_RS00560 113866..114597 - 732 Protein_111 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..124247 124247


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 22704.83 Da        Isoelectric Point: 13.0455

>T156889 WP_171774034.1 NZ_CP053580:109206-109736 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKK

Download         Length: 531 bp

>T156889 NZ_CP069072:3176906-3177169 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT156889 WP_171774033.1 NZ_CP053580:108933-109202 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT156889 NZ_CP069072:3176621-3176902 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References