Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 43692..44243 Replicon plasmid unnamed2
Accession NZ_CP053577
Organism Salmonella enterica strain 2012K-0845

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HPG82_RS00610 Protein ID WP_079893814.1
Coordinates 43926..44243 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag HPG82_RS00605 Protein ID WP_079893815.1
Coordinates 43692..43922 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPG82_RS00580 39327..40544 + 1218 WP_079893820.1 OpgC domain-containing protein -
HPG82_RS00585 40555..41454 + 900 WP_079893819.1 hypothetical protein -
HPG82_RS00590 41463..42677 + 1215 WP_079893818.1 SpoIIE family protein phosphatase -
HPG82_RS00595 42667..43005 + 339 WP_079893817.1 STAS domain-containing protein -
HPG82_RS00600 43025..43432 + 408 WP_139762360.1 ATP-binding protein -
HPG82_RS00605 43692..43922 + 231 WP_079893815.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HPG82_RS00610 43926..44243 + 318 WP_079893814.1 CcdB family protein Toxin
HPG82_RS00615 44352..46031 - 1680 WP_079893813.1 SgrR family transcriptional regulator -
HPG82_RS00620 46254..47780 + 1527 WP_079893812.1 glucose-specific PTS transporter subunit IIBC -
HPG82_RS00625 47777..48619 + 843 WP_079893811.1 cytoplasmic protein -
HPG82_RS00630 48619..49182 + 564 WP_079893858.1 6-phospho-3-hexuloisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..215249 215249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 13604.47 Da        Isoelectric Point: 12.8211

>T156886 WP_079893814.1 NZ_CP053577:43926-44243 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 318 bp

>T156886 NZ_CP069072:c3109640-3109284 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT156886 WP_079893815.1 NZ_CP053577:43692-43922 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT156886 NZ_CP069072:c3109854-3109624 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References