Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 18532..19187 Replicon plasmid unnamed2
Accession NZ_CP053577
Organism Salmonella enterica strain 2012K-0845

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HPG82_RS00510 Protein ID WP_079893834.1
Coordinates 18759..19187 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HPG82_RS00505 Protein ID WP_001658402.1
Coordinates 18532..18762 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPG82_RS00485 14294..15499 - 1206 WP_000427673.1 AAA family ATPase -
HPG82_RS00490 15621..16403 - 783 WP_079893835.1 site-specific integrase -
HPG82_RS00495 16400..16834 - 435 WP_000429589.1 hypothetical protein -
HPG82_RS00500 16903..17556 - 654 WP_000796234.1 hypothetical protein -
HPG82_RS00505 18532..18762 + 231 WP_001658402.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HPG82_RS00510 18759..19187 + 429 WP_079893834.1 type II toxin-antitoxin system VapC family toxin Toxin
HPG82_RS00515 20102..20485 - 384 WP_193323156.1 DUF4365 domain-containing protein -
HPG82_RS00520 20720..21172 - 453 WP_079893831.1 NUDIX domain-containing protein -
HPG82_RS00525 21326..21874 - 549 WP_079893830.1 AAA family ATPase -
HPG82_RS00530 22966..23571 + 606 Protein_32 Polarity suppression protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..215249 215249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 18346.91 Da        Isoelectric Point: 12.9522

>T156885 WP_079893834.1 NZ_CP053577:18759-19187 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 429 bp

>T156885 NZ_CP069072:c3070449-3070054 [Mycobacterium tuberculosis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT156885 WP_001658402.1 NZ_CP053577:18532-18762 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT156885 NZ_CP069072:c3070028-3069762 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References