Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3660232..3660852 Replicon chromosome
Accession NZ_CP053573
Organism Citrobacter sp. TSA-1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HF677_RS17515 Protein ID WP_002892050.1
Coordinates 3660634..3660852 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag HF677_RS17510 Protein ID WP_019076175.1
Coordinates 3660232..3660606 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF677_RS17500 3655379..3656572 + 1194 WP_047416860.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HF677_RS17505 3656595..3659744 + 3150 WP_016152073.1 multidrug efflux RND transporter permease subunit -
HF677_RS17510 3660232..3660606 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
HF677_RS17515 3660634..3660852 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HF677_RS17520 3661033..3661584 + 552 WP_046276082.1 maltose O-acetyltransferase -
HF677_RS17525 3661701..3662171 + 471 WP_016152071.1 YlaC family protein -
HF677_RS17530 3662250..3662390 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HF677_RS17535 3662392..3662652 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
HF677_RS17540 3662841..3664394 + 1554 WP_080858963.1 EAL domain-containing protein -
HF677_RS17545 3664446..3664799 - 354 WP_080858962.1 DUF1428 family protein -
HF677_RS17550 3664864..3665493 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T156878 WP_002892050.1 NZ_CP053573:3660634-3660852 [Citrobacter sp. TSA-1]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T156878 NZ_CP069072:c2855070-2854651 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT156878 WP_019076175.1 NZ_CP053573:3660232-3660606 [Citrobacter sp. TSA-1]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT156878 NZ_CP069072:c2855291-2855067 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References