Detailed information of TA system TA156869

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 866030..866684
• Replicon: chromosome
• Accession: NZ_CP053573
• Organism: Citrobacter sp. TSA-1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: R8WN60
• Locus tag: HF677_RS04155
• Protein ID: WP_016154348.1
• Coordinates: 866277..866684 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: R8WMJ6
• Locus tag: HF677_RS04150
• Protein ID: WP_016154349.1
• Coordinates: 866030..866296 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF677_RS04125	861243..862676	-	1434	WP_095716013.1	6-phospho-beta-glucosidase BglA	-
HF677_RS04130	862797..863525	-	729	WP_008785744.1	MurR/RpiR family transcriptional regulator	-
HF677_RS04135	863578..863889	+	312	WP_016154352.1	N(4)-acetylcytidine aminohydrolase	-
HF677_RS04140	864053..864712	+	660	WP_016154351.1	hemolysin III family protein	-
HF677_RS04145	864792..865772	-	981	WP_095716012.1	tRNA-modifying protein YgfZ	-
HF677_RS04150	866030..866296	+	267	WP_016154349.1	FAD assembly factor SdhE	Antitoxin
HF677_RS04155	866277..866684	+	408	WP_016154348.1	protein YgfX	Toxin
HF677_RS04160	866785..867306	-	522	WP_016154347.1	flavodoxin FldB	-
HF677_RS04165	867420..868316	+	897	WP_046274931.1	site-specific tyrosine recombinase XerD	-
HF677_RS04170	868340..869053	+	714	WP_016154345.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HF677_RS04175	869059..870792	+	1734	WP_016157413.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15850.66 Da
• Isoelectric Point: 11.2845

>T156869 WP_016154348.1 NZ_CP053573:866277-866684 [Citrobacter sp. TSA-1]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Nucleotide

• Length: 408 bp

>T156869 NZ_CP069072:c2198123-2197827 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10557.10 Da
• Isoelectric Point: 5.6375

>AT156869 WP_016154349.1 NZ_CP053573:866030-866296 [Citrobacter sp. TSA-1]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT156869 NZ_CP069072:c2198371-2198120 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Structures

Toxin

• AlphaFold DB: R8WN60

Antitoxin

• AlphaFold DB: R8WMJ6