Detailed information of TA system TA156868

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4137127..4137796
• Replicon: chromosome
• Accession: NZ_CP053572
• Organism: Serratia marcescens strain S7.1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: F0335_RS19840
• Protein ID: WP_063990696.1
• Coordinates: 4137127..4137549 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: F0335_RS19845
• Protein ID: WP_019455657.1
• Coordinates: 4137530..4137796 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0335_RS19820	4133016..4133534	+	519	WP_038871234.1	flavodoxin FldB	-
F0335_RS19825	4133572..4134936	-	1365	WP_130018208.1	cell envelope integrity protein CreD	-
F0335_RS19830	4135017..4136435	-	1419	WP_107227933.1	two-component system sensor histidine kinase CreC	-
F0335_RS19835	4136432..4137127	-	696	WP_149559831.1	two-component system response regulator CreB	-
F0335_RS19840	4137127..4137549	-	423	WP_063990696.1	protein YgfX	Toxin
F0335_RS19845	4137530..4137796	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
F0335_RS19850	4138117..4139109	+	993	WP_063990695.1	tRNA-modifying protein YgfZ	-
F0335_RS19855	4139148..4139645	-	498	WP_063990694.1	DUF2165 domain-containing protein	-
F0335_RS19860	4139796..4140470	-	675	WP_033639467.1	hemolysin III family protein	-
F0335_RS19865	4140654..4141262	+	609	WP_025304127.1	HD domain-containing protein	-
F0335_RS19870	4141295..4142221	-	927	WP_038871218.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16510.60 Da
• Isoelectric Point: 10.8114

>T156868 WP_063990696.1 NZ_CP053572:c4137549-4137127 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFNWHGR
EWRLAKKPWMPGYGMLLTLLPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEEP

Nucleotide

• Length: 423 bp

>T156868 NZ_CP069072:2195865-2196242 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT156868 WP_019455657.1 NZ_CP053572:c4137796-4137530 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT156868 NZ_CP069072:2196284-2196733 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04