Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3738361..3739017 Replicon chromosome
Accession NZ_CP053572
Organism Serratia marcescens strain S7.1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F0335_RS17920 Protein ID WP_149559454.1
Coordinates 3738361..3738750 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F0335_RS17925 Protein ID WP_107227830.1
Coordinates 3738754..3739017 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0335_RS17905 3734828..3736258 + 1431 WP_175089952.1 multidrug transporter subunit MdtD -
F0335_RS17910 3736255..3737637 + 1383 WP_107227832.1 two-component system sensor histidine kinase BaeS -
F0335_RS17915 3737637..3738353 + 717 WP_063990502.1 two-component system response regulator BaeR -
F0335_RS17920 3738361..3738750 - 390 WP_149559454.1 type II toxin-antitoxin system VapC family toxin Toxin
F0335_RS17925 3738754..3739017 - 264 WP_107227830.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F0335_RS17930 3739356..3739694 + 339 WP_016926703.1 YegP family protein -
F0335_RS17935 3739872..3741224 + 1353 WP_149559455.1 tRNA 5-hydroxyuridine modification protein YegQ -
F0335_RS17940 3741691..3742596 + 906 WP_063990506.1 lipid kinase YegS -
F0335_RS17945 3742766..3743980 + 1215 WP_149559456.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14369.50 Da        Isoelectric Point: 7.9048

>T156867 WP_149559454.1 NZ_CP053572:c3738750-3738361 [Serratia marcescens]
MYMFDTNTISHLFRQHPQVLNIMEKHPPSAVCISSVTEAELLYGVAKRRNKALQSAVEAFLAAVTVYAWDSEAARCYGEM
RANMERRGKIMGALDQLIAAHAQSRGATLVTNDRAFTLVPGLAVEDWTR

Download         Length: 390 bp

>T156867 NZ_CP069072:c2189119-2188790 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10022.29 Da        Isoelectric Point: 4.8537

>AT156867 WP_107227830.1 NZ_CP053572:c3739017-3738754 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKSDSWAPLLSIIAQTPVPQEFLGVEDRQQGVAGR
DPFSEEE

Download         Length: 264 bp

>AT156867 NZ_CP069072:c2189493-2189116 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References