Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1055481..1056102 Replicon chromosome
Accession NZ_CP053572
Organism Serratia marcescens strain S7.1

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag F0335_RS04965 Protein ID WP_004940313.1
Coordinates 1055481..1055684 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag F0335_RS04970 Protein ID WP_004940312.1
Coordinates 1055734..1056102 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0335_RS04935 1051180..1051518 + 339 WP_004940327.1 P-II family nitrogen regulator -
F0335_RS04940 1051555..1052841 + 1287 WP_063990981.1 ammonium transporter AmtB -
F0335_RS04945 1052932..1053795 - 864 WP_004940320.1 acyl-CoA thioesterase II -
F0335_RS04950 1054027..1054518 + 492 WP_060426627.1 YbaY family lipoprotein -
F0335_RS04955 1054583..1054897 - 315 WP_019454177.1 MGMT family protein -
F0335_RS04965 1055481..1055684 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
F0335_RS04970 1055734..1056102 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
F0335_RS04975 1056261..1056614 - 354 WP_063990982.1 hypothetical protein -
F0335_RS04980 1057024..1057737 + 714 WP_149559388.1 ABC transporter ATP-binding protein -
F0335_RS04985 1057734..1058591 + 858 WP_063990984.1 metal ABC transporter permease -
F0335_RS04990 1058617..1059495 + 879 WP_049199910.1 metal ABC transporter substrate-binding protein -
F0335_RS04995 1059602..1059742 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
F0335_RS05000 1059755..1060009 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T156857 WP_004940313.1 NZ_CP053572:c1055684-1055481 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T156857 NZ_CP069072:c1234202-1233891 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACACCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT156857 WP_004940312.1 NZ_CP053572:c1056102-1055734 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT156857 NZ_CP069072:c1234522-1234202 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References