156852

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4920417..4921077 Replicon chromosome
Accession NZ_CP053568
Organism Enterobacter cloacae strain MY490

Toxin (Protein)


Gene name cptA Uniprot ID A0A5E1AGQ2
Locus tag HPB40_RS23880 Protein ID WP_023620447.1
Coordinates 4920417..4920830 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag HPB40_RS23885 Protein ID WP_013098615.1
Coordinates 4920811..4921077 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPB40_RS23860 (HPB40_23795) 4916410..4918143 - 1734 WP_013098610.1 single-stranded-DNA-specific exonuclease RecJ -
HPB40_RS23865 (HPB40_23800) 4918149..4918862 - 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HPB40_RS23870 (HPB40_23805) 4918891..4919787 - 897 WP_013098612.1 site-specific tyrosine recombinase XerD -
HPB40_RS23875 (HPB40_23810) 4919889..4920410 + 522 WP_013098613.1 flavodoxin FldB -
HPB40_RS23880 (HPB40_23815) 4920417..4920830 - 414 WP_023620447.1 protein YgfX Toxin
HPB40_RS23885 (HPB40_23820) 4920811..4921077 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
HPB40_RS23890 (HPB40_23825) 4921372..4922352 + 981 WP_126347811.1 tRNA-modifying protein YgfZ -
HPB40_RS23895 (HPB40_23830) 4922462..4923121 - 660 WP_003863433.1 hemolysin III family protein -
HPB40_RS23900 (HPB40_23835) 4923387..4924118 + 732 WP_126347812.1 MurR/RpiR family transcriptional regulator -
HPB40_RS23905 (HPB40_23840) 4924235..4925668 + 1434 WP_020687084.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16220.21 Da        Isoelectric Point: 10.9554

>T156852 WP_023620447.1 NZ_CP053568:c4920830-4920417 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRELRRMLLQQQPTQE

Download         Length: 414 bp

>T156852 NZ_CP069072:c758965-758528 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT156852 WP_013098615.1 NZ_CP053568:c4921077-4920811 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT156852 NZ_CP069072:c758418-758173 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AGQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References