156842

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2026335..2026955 Replicon chromosome
Accession NZ_CP053568
Organism Enterobacter cloacae strain MY490

Toxin (Protein)


Gene name Hha Uniprot ID A0A5E1A1U8
Locus tag HPB40_RS09590 Protein ID WP_013095889.1
Coordinates 2026335..2026553 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag HPB40_RS09595 Protein ID WP_008499288.1
Coordinates 2026581..2026955 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPB40_RS09560 (HPB40_09505) 2022347..2022607 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
HPB40_RS09565 (HPB40_09510) 2022610..2022750 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HPB40_RS09570 (HPB40_09515) 2022747..2023457 - 711 WP_013095885.1 GNAT family protein -
HPB40_RS09575 (HPB40_09520) 2023559..2025019 + 1461 WP_013095886.1 PLP-dependent aminotransferase family protein -
HPB40_RS09580 (HPB40_09525) 2024991..2025458 - 468 WP_013095887.1 YlaC family protein -
HPB40_RS09585 (HPB40_09530) 2025574..2026125 - 552 WP_013095888.1 maltose O-acetyltransferase -
HPB40_RS09590 (HPB40_09535) 2026335..2026553 - 219 WP_013095889.1 HHA domain-containing protein Toxin
HPB40_RS09595 (HPB40_09540) 2026581..2026955 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
HPB40_RS09600 (HPB40_09545) 2027468..2030614 - 3147 WP_013095890.1 multidrug efflux RND transporter permease subunit AcrB -
HPB40_RS09605 (HPB40_09550) 2030637..2031830 - 1194 WP_023620093.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8625.98 Da        Isoelectric Point: 8.9008

>T156842 WP_013095889.1 NZ_CP053568:c2026553-2026335 [Enterobacter cloacae]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

>T156842 NZ_CP069072:c643301-642888 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT156842 WP_008499288.1 NZ_CP053568:c2026955-2026581 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT156842 NZ_CP069072:c643564-643298 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1A1U8

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References