Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1828153..1828811 Replicon chromosome
Accession NZ_CP053568
Organism Enterobacter cloacae strain MY490

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HPB40_RS08680 Protein ID WP_032637385.1
Coordinates 1828153..1828473 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HPB40_RS08685 Protein ID WP_032637384.1
Coordinates 1828494..1828811 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPB40_RS08660 (HPB40_08605) 1823202..1824740 + 1539 WP_032637388.1 sugar ABC transporter ATP-binding protein -
HPB40_RS08665 (HPB40_08610) 1824764..1825825 + 1062 WP_001581452.1 ABC transporter permease -
HPB40_RS08670 (HPB40_08615) 1825914..1826864 + 951 WP_001581454.1 D-ribose ABC transporter substrate-binding protein -
HPB40_RS08675 (HPB40_08620) 1826995..1827852 + 858 WP_001581455.1 DeoR/GlpR family DNA-binding transcription regulator -
HPB40_RS08680 (HPB40_08625) 1828153..1828473 - 321 WP_032637385.1 TA system toxin CbtA family protein Toxin
HPB40_RS08685 (HPB40_08630) 1828494..1828811 - 318 WP_032637384.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HPB40_RS08690 (HPB40_08635) 1828830..1829051 - 222 WP_032637383.1 DUF987 domain-containing protein -
HPB40_RS08695 (HPB40_08640) 1829060..1829536 - 477 WP_000811693.1 RadC family protein -
HPB40_RS08700 (HPB40_08645) 1829552..1830010 - 459 WP_000211838.1 antirestriction protein -
HPB40_RS08705 (HPB40_08650) 1830108..1830347 - 240 WP_000194654.1 DUF905 family protein -
HPB40_RS08710 (HPB40_08655) 1830424..1830891 - 468 WP_001547765.1 protein YkfB -
HPB40_RS08715 (HPB40_08660) 1830914..1831357 - 444 WP_001547764.1 lipoprotein YafY -
HPB40_RS08720 (HPB40_08665) 1831357..1831593 - 237 WP_001144031.1 protein YpjK -
HPB40_RS08725 (HPB40_08670) 1831634..1832335 - 702 WP_126347823.1 WYL domain-containing protein -
HPB40_RS08730 (HPB40_08675) 1832552..1833373 - 822 WP_001547762.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-104)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12146.14 Da        Isoelectric Point: 7.1656

>T156841 WP_032637385.1 NZ_CP053568:c1828473-1828153 [Enterobacter cloacae]
MKTLPATTLWAAKPCPSPVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPFITAVDILKARRAMREMRT

Download         Length: 321 bp

>T156841 NZ_CP069072:c447499-446906 [Mycobacterium tuberculosis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12020.58 Da        Isoelectric Point: 6.7389

>AT156841 WP_032637384.1 NZ_CP053568:c1828811-1828494 [Enterobacter cloacae]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTDELNPRHAHCVTLYH
NGFTCEADTLGSCGYVYITVYPTHR

Download         Length: 318 bp

>AT156841 NZ_CP069072:c447917-447528 [Mycobacterium tuberculosis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References