156839

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1353805..1354321 Replicon chromosome
Accession NZ_CP053568
Organism Enterobacter cloacae strain MY490

Toxin (Protein)


Gene name relE Uniprot ID A0A0M7F3X9
Locus tag HPB40_RS06555 Protein ID WP_013095355.1
Coordinates 1354037..1354321 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag HPB40_RS06550 Protein ID WP_008501400.1
Coordinates 1353805..1354047 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPB40_RS06535 (HPB40_06490) 1349794..1350534 + 741 WP_013095353.1 KDGP aldolase family protein -
HPB40_RS06540 (HPB40_06495) 1350658..1351797 + 1140 WP_100168201.1 lactonase family protein -
HPB40_RS06545 (HPB40_06500) 1351817..1353727 + 1911 WP_126347509.1 PRD domain-containing protein -
HPB40_RS06550 (HPB40_06505) 1353805..1354047 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPB40_RS06555 (HPB40_06510) 1354037..1354321 + 285 WP_013095355.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPB40_RS06560 (HPB40_06515) 1354325..1354789 - 465 WP_013095356.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HPB40_RS06565 (HPB40_06520) 1354912..1357050 - 2139 WP_013095357.1 anaerobic ribonucleoside-triphosphate reductase -
HPB40_RS06570 (HPB40_06525) 1357424..1359067 - 1644 WP_013095358.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10986.92 Da        Isoelectric Point: 10.4251

>T156839 WP_013095355.1 NZ_CP053568:1354037-1354321 [Enterobacter cloacae]
MTYELEFDPRALKEWSKLGETVKKQFKKKLAGVLVNPRIESARLHNLPDCYKIKLRSQGYRLVYQVQDNVVTVVVIAIGK
REKLTVYHDANKRL

Download         Length: 285 bp

>T156839 NZ_CP069072:366175-366477 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT156839 WP_008501400.1 NZ_CP053568:1353805-1354047 [Enterobacter cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT156839 NZ_CP069072:366525-366746 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M7F3X9

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References