Detailed information of TA system TA156835

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 6147823..6148454
• Replicon: chromosome
• Accession: NZ_CP053564
• Organism: Pseudonocardia broussonetiae strain Gen 01

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HOP40_RS29860
• Protein ID: WP_172165206.1
• Coordinates: 6147823..6148221 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HOP40_RS29865
• Protein ID: WP_172165209.1
• Coordinates: 6148218..6148454 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HOP40_RS29835	6142850..6144418	+	1569	WP_172165191.1	alpha/beta fold hydrolase	-
HOP40_RS29840	6144449..6145783	-	1335	WP_172165194.1	DUF732 domain-containing protein	-
HOP40_RS29845	6145986..6147023	-	1038	WP_172165197.1	non-homologous end-joining DNA ligase	-
HOP40_RS29850	6147055..6147342	+	288	WP_172165200.1	hypothetical protein	-
HOP40_RS29855	6147402..6147830	+	429	WP_172165203.1	peptide-methionine (R)-S-oxide reductase MsrB	-
HOP40_RS29860	6147823..6148221	-	399	WP_172165206.1	type II toxin-antitoxin system VapC family toxin	Toxin
HOP40_RS29865	6148218..6148454	-	237	WP_172165209.1	antitoxin	Antitoxin
HOP40_RS29870	6148488..6149183	-	696	WP_172165212.1	chlorite dismutase family protein	-
HOP40_RS29875	6149219..6151141	+	1923	WP_172165215.1	ATP-binding protein	-
HOP40_RS29880	6151169..6152506	+	1338	WP_172165218.1	FAD-dependent monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 13649.82 Da
• Isoelectric Point: 7.4217

>T156835 WP_172165206.1 NZ_CP053564:c6148221-6147823 [Pseudonocardia broussonetiae]
VNGLVLDASVAAIAVVEATPQGDALRARLVANPVHAPHLVDAEVGSVLRRHAAAGLIEPAQAAGALRMLSTLVTDRYPHG
PLSGPAWSLRHNLSFYDALYVALAARLAVPLLTADARLARAPGLPCAVEVIS

Nucleotide

• Length: 399 bp

>T156835 NZ_CP069071:c3790717-3790325 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9297.42 Da
• Isoelectric Point: 7.2043

>AT156835 WP_172165209.1 NZ_CP053564:c6148454-6148218 [Pseudonocardia broussonetiae]
MATIQVRDIPDDVYKTIRRRAREAGQSLQAYMRDQVVALGSRPDRAEILADWERELHQHPNTITREQILRDLDDDRRR

Nucleotide

• Length: 237 bp

>AT156835 NZ_CP069071:c3790992-3790717 [Mycobacterium tuberculosis]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA