Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2765301..2765932 Replicon chromosome
Accession NZ_CP053564
Organism Pseudonocardia broussonetiae strain Gen 01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HOP40_RS13875 Protein ID WP_172158468.1
Coordinates 2765525..2765932 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HOP40_RS13870 Protein ID WP_205347191.1
Coordinates 2765301..2765528 (+) Length 76 a.a.

Genomic Context

HOP40_RS13845HOP40_RS13850HOP40_RS13855HOP40_RS13860HOP40_RS13865HOP40_RS13870HOP40_RS13875HOP40_RS13890HOP40_RS13895HOP40_RS13900HOP40_RS13880HOP40_RS13885HOP40_RS13905
Location: 2760990..2762099 (1110 bp)
Type: Others
Protein ID: WP_172158465.1
Location: 2762116..2762769 (654 bp)
Type: Others
Protein ID: WP_172158466.1
Location: 2762769..2763539 (771 bp)
Type: Others
Protein ID: WP_172168316.1
Location: 2763592..2764476 (885 bp)
Type: Others
Protein ID: WP_172168320.1
Location: 2764479..2765270 (792 bp)
Type: Others
Protein ID: WP_205347190.1
Location: 2765301..2765528 (228 bp)
Type: Antitoxin
Protein ID: WP_205347191.1
Location: 2765525..2765932 (408 bp)
Type: Toxin
Protein ID: WP_172158468.1
Location: 2767020..2767406 (387 bp)
Type: Others
Protein ID: WP_172158474.1
Location: 2767403..2768923 (1521 bp)
Type: Others
Protein ID: WP_172158485.1
Location: 2768966..2769487 (522 bp)
Type: Others
Protein ID: WP_172158488.1
Location: 2765910..2766596 (687 bp)
Type: Others
Protein ID: WP_172158469.1
Location: 2766593..2766931 (339 bp)
Type: Others
Protein ID: WP_172158471.1
Location: 2769503..2770789 (1287 bp)
Type: Others
Protein ID: WP_172158490.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HOP40_RS138452760990..2762099+1110WP_172158465.1ATP-binding cassette domain-containing protein-
HOP40_RS138502762116..2762769+654WP_172158466.1ABC transporter permease subunit-
HOP40_RS138552762769..2763539+771WP_172168316.1ABC transporter permease-
HOP40_RS138602763592..2764476+885WP_172168320.1ABC transporter substrate-binding protein-
HOP40_RS138652764479..2765270+792WP_205347190.1MOSC domain-containing protein-
HOP40_RS138702765301..2765528+228WP_205347191.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
HOP40_RS138752765525..2765932+408WP_172158468.1PIN domain nucleaseToxin
HOP40_RS138802765910..2766596-687WP_172158469.1hypothetical protein-
HOP40_RS138852766593..2766931-339WP_172158471.1helix-turn-helix transcriptional regulator-
HOP40_RS138902767020..2767406+387WP_172158474.1hypothetical protein-
HOP40_RS138952767403..2768923+1521WP_172158485.1multicopper oxidase domain-containing protein-
HOP40_RS139002768966..2769487+522WP_172158488.1DUF5134 domain-containing protein-
HOP40_RS139052769503..2770789-1287WP_172158490.1Nramp family divalent metal transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-43)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14559.84 Da        Isoelectric Point: 5.9009

>T156833 WP_172158468.1 NZ_CP053564:2765525-2765932 [Pseudonocardia broussonetiae]
VNLVDSSAWIEFLRRTGSAANLEVRRLLREEPGSVAITEPVVVELLAGANSDRSLAQIEKLVDGVVLLPVDAALDYRDAA
VVYRAVRARGGTVRKLVDCLIAVVAVRTGAALVHRDRDFDVLAAALPELTVRSFV

Download         Length: 408 bp

>T156833 NZ_CP069071:c3700316-3699888 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8407.42 Da        Isoelectric Point: 4.5127

>AT156833 WP_205347191.1 NZ_CP053564:2765301-2765528 [Pseudonocardia broussonetiae]
MGRTNIDIDDELIAEVMRRHSLRTKKEAVDLALRRLVGPRLSPEFFEGLEGIGWDGDLDEMRGSRIHDGDGVDAS

Download         Length: 228 bp

>AT156833 NZ_CP069071:c3700562-3700320 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References